NAT8 and TMEM143

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NAT8	TMEM143
Description		N-acetyltransferase 8 (putative)	transmembrane protein 143
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Mitochondrion Membrane
	Molecular Function	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups L-cysteine-S-conjugate N-acetyltransferase Activity Protein-lysine-acetyltransferase Activity	Molecular_function Protein Binding
	Biological Process	Glutathione Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine N6-acetylation Amyloid Fibril Formation	Biological_process
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 23535967) Glomerular filtration rate (creatinine) ( 28452372) Hemoglobin levels ( 32327693) Macrovascular complications in type 2 diabetes ( 33430853) Metabolic traits ( 21886157) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 33031748 24625756 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 26352407)
Interacting Genes		31 interacting genes: AQP6 ARL13B ATP6V0E1 BIK CD79A CERS4 CREB3L1 EBP FAM209A FFAR2 GOLT1A GPR152 HSD17B13 JPH1 LEPROTL1 LMNA MTIF3 REEP2 SAR1A SLC10A6 SLC71A2 SMAD4 TGFBR1 TLCD4 TMEM143 TMEM14B TMEM31 TMX2 TRIM21 TSPAN31 YIPF4	14 interacting genes: ABHD16A AQP6 CSGALNACT2 DGAT2L6 DHRSX LIME1 LSMEM2 NAT8 ORMDL1 REEP6 SFT2D2 SLC10A6 TMEM120B YIPF2
Entrez ID		9027	55260
HPRD ID		08413	08556
Ensembl ID		ENSG00000144035	ENSG00000161558
Uniprot IDs		Q9UHE5	B4DMT0 B4DPF8 Q96AN5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum	Nitrate Transmembrane Transporter Activity Membrane Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus L-cysteine-S-conjugate N-acetyltransferase Activity Dolichal Reductase (NADPH) Activity Polyprenol Dehydrogenase (NAD+) Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Intracellular Transport Of Viral Protein In Host Cell Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Peptidyl-lysine N6-acetylation Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity Acylglycerol Acyl-chain Remodeling Phospholipid Metabolic Process Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Monoacylglycerol Catabolic Process B Cell Receptor Complex Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Bile Acid:sodium Symporter Activity Diacylglycerol O-acyltransferase Activity
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