TRIM29 and HINT1

Number of citations of the paper that reports this interaction (PMID 7644499)
11

Data Source:
HPRD (in vitro)

		TRIM29	HINT1
Gene Name		tripartite motif containing 29	histidine triad nucleotide binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Intermediate Filament Cytoskeleton	Histone Deacetylase Complex Nucleus Cytoplasm Cytoskeleton Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	P53 Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding	Nucleotide Binding Protein Kinase C Binding Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Localization To Nucleus	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Signal Transduction Purine Ribonucleotide Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs			Adenosine monophosphate Guanosine-5\'-Monophosphate 5\'-O-(N-Ethyl-Sulfamoyl)Adenosine Adenosine-5\'-Ditungstate 8-Bromo-Adenosine-5\'-Monophosphate
Diseases
GWAS		Corneal curvature ( 22969067) Stroke (pediatric) ( 22990015)
Protein-Protein Interactions		40 interactors: CARD9 CEP70 CRACR2A DMRT1 FBF1 FBXL19 FXR2 GATA1 GCC1 GOLGA2 GTF2E1 HCLS1 HDAC9 HINT1 IKBKG JAKMIP2 KAT5 LZTS2 MAD1L1 MED7 MID2 MLH1 MYO15B PARP1 POLR2D POLR2E PRICKLE3 PRKCA SHOX2 SMAD9 SNAPC1 SP100 TAX1BP3 TRIM11 TRIM23 TRIM27 TRIP6 TSGA10 UBE2I VIM	4 interactors: CDC16 MITF SP1 TRIM29
Entrez ID		23650	3094
HPRD ID		10280	03204
Ensembl ID		ENSG00000137699
Uniprot IDs		B7Z8U9 E9PRL4 Q14134	P49773
PDB IDs		2CSV	1AV5 1KPA 1KPB 1KPC 1KPE 1KPF 3TW2 4EQE 4EQG 4EQH
Enriched GO Terms of Interacting Partners?		Regulation Of Viral Transcription Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Viral Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Viral Process Regulation Of Viral Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of Viral Release From Host Cell Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression RNA Metabolic Process Immune System Process Intracellular Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Differentiation Regulation Of Cellular Localization Regulation Of Protein Localization DNA-templated Transcription, Initiation Innate Immune Response Organelle Organization Regulation Of Signal Transduction Cellular Macromolecule Biosynthetic Process Spindle Midzone Assembly Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Signal Transduction Transcription Elongation From RNA Polymerase II Promoter Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Sequestering Of Nodal From Receptor Via Nodal Binding Transcription From RNA Polymerase II Promoter Negative Regulation Of Nodal Signaling Pathway Myeloid Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Regulation Of Nodal Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Camera-type Eye Development Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation By Host Of Viral Transcription Eye Development Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Process Involved In Female Pregnancy Lateral Mesoderm Development Enucleate Erythrocyte Differentiation Negative Regulation Of Cellular Metabolic Process Extracellular Negative Regulation Of Signal Transduction Transcription, DNA-templated Sensory Organ Development Atrial Septum Development Megakaryocyte Differentiation Regulation Of Activin Receptor Signaling Pathway Protein K11-linked Ubiquitination RNA Biosynthetic Process Definitive Hemopoiesis Hemopoiesis Trophectodermal Cell Differentiation Positive Regulation Of Cellular Metabolic Process Immune System Development Interaction With Symbiont Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Transcription From RNA Polymerase II Promoter Melanocyte Differentiation Mitotic Spindle Checkpoint Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Chromosome Segregation Negative Regulation Of BMP Signaling Pathway Embryonic Eye Morphogenesis Osteoclast Differentiation Positive Regulation Of Viral Transcription Neuroepithelial Cell Differentiation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition RNA Metabolic Process Ventricular Septum Development
Tagcloud ?		adenocarcinoma ataxia atdc atm basis candidacy damaging directly ductal improve ionizing leading mapkap mk2 pancreatic pdac phosphorylated poorly radiation radioprotective radioresistance radiosensitize repair ser ser550 telangiectasia therapeutic understood xenograft	attenuating beta1 capable catenin ccl4 dawley engineering exists fibrosis histidine histopathological hydroxyproline liver lowered pathogenic simultaneously sma smad smad3 smad7 sought sprague subcutaneous tetrachloride tgf transforming triad vital
Tagcloud (Difference) ?		adenocarcinoma ataxia atdc atm basis candidacy damaging directly ductal improve ionizing leading mapkap mk2 pancreatic pdac phosphorylated poorly radiation radioprotective radioresistance radiosensitize repair ser ser550 telangiectasia therapeutic understood xenograft	attenuating beta1 capable catenin ccl4 dawley engineering exists fibrosis histidine histopathological hydroxyproline liver lowered pathogenic simultaneously sma smad smad3 smad7 sought sprague subcutaneous tetrachloride tgf transforming triad vital
Tagcloud (Intersection) ?