EDAR and EDA

Number of citations: 0 (PubMedID 11309369)
Data Source: HPRD (in vivo, in vitro)

		EDAR	EDA
Name		ectodysplasin A receptor	ectodysplasin A
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Part Of Cell	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity
	Biological Process	Hair Follicle Development Apoptotic Process Epidermis Development Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Positive Regulation Of JNK Cascade Salivary Gland Cavitation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Hair Follicle Development Immune Response Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Skin Development Canonical Wnt Signaling Pathway Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic	Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Beard thickness ( 26926045 ) Blood protein levels ( 30072576 ) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761 ) Ear morphology ( 26105758 ) Ear protrusion ( 26105758 ) Eyebrow thickness ( 30248107 ) Helix rolling ( 26105758 ) Lobe attachment ( 26105758 ) Lobe attachment (rater scored) ( 29198719 ) Lobe size ( 26105758 ) lower facial morphology traits (quantitative measurement) ( 27193062 ) Lung function (FVC) ( 30061609 ) Male-pattern baldness ( 27182965 ) Monobrow ( 27182965 ) Monobrow thickness ( 26926045 ) Scalp hair shape ( 26926045 ) Straight vs curly hair ( 27487801 29895819 ) Thick vs thin eyebrows ( 29895819 ) Urinary albumin-to-creatinine ratio ( 32600054 )	Male-pattern baldness ( 30573740 ) Metabolite levels ( 23823483 ) Monobrow ( 27182965 ) Primary tooth development (number of teeth) ( 20195514 23704328 ) Primary tooth development (time to first tooth eruption) ( 20195514 23704328 ) Tooth agenesis (maxillary lateral incisors) ( 29364747 )
Interacting Genes		8 interacting genes: EDA EDARADD MAP3K14 SGTA TRAF1 TRAF2 TRAF3 UPK1B	23 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60
Entrez ID		10913	1896
HPRD ID		04974	02347
Ensembl ID		ENSG00000135960	ENSG00000158813
Uniprot IDs		Q9UNE0	A0A0U5J797 Q92838
PDB IDs		7X9G	1RJ7 1RJ8 7X9G
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding TORC2 Complex Disassembly Positive Regulation Of NF-kappaB Transcription Factor Activity Trachea Gland Development TRC Complex Protein Phosphatase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Response To Other Organism Ubiquitin Ligase Complex Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Immune Response Apical Plasma Membrane Urothelial Plaque Death Receptor Agonist Activity BAT3 Complex Binding Sphingolipid Binding Response To External Biotic Stimulus IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Hair Follicle Placode Formation Salivary Gland Cavitation CD27 Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of ERAD Pathway Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Toll Signaling Pathway Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRIF-dependent Toll-like Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of JUN Kinase Activity Ubiquitin-protein Transferase Activity Immune System Process	Bleb Assembly Membrane Lysosomal Membrane Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Epidermis Development Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Dolichol Kinase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity