EDAR and TRAF1

Number of citations of the paper that reports this interaction (PMID 11035039)
22

Data Source:
HPRD (in vivo)

		EDAR	TRAF1
Gene Name		ectodysplasin A receptor	TNF receptor-associated factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Part Of Cell	Cytoplasm
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding
	Biological Process	Hair Follicle Development Apoptotic Process Signal Transduction Epidermis Development Cell Differentiation Positive Regulation Of NF-kappaB Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Pigmentation Salivary Gland Cavitation	Protein Complex Assembly Apoptotic Process Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842 19503088)
Protein-Protein Interactions		6 interactors: EDA EDARADD MAP3K14 TRAF1 TRAF2 TRAF3	164 interactors: A1CF ACTN3 AES AKAP17A ALS2CR11 AQP1 ARNT2 ARSJ BARD1 BCL6 BEX2 BIRC2 BIRC3 C14orf105 C19orf66 C1orf109 C1orf216 C5orf30 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCHCR1 CD40 CDCA3 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 ECH1 EDAR EHHADH EWSR1 FAM161A FAM86C1 FBF1 FBXL18 FOSL2 GATA2 GATAD2B GEM GFI1B GIT2 GLRX3 GMCL1P1 GNG5 GORASP2 HAUS1 HEY2 HIVEP3 HOXA1 HOXD12 IKBKB JOSD1 KIAA1217 KIF1A KLHL38 KPNA2 LATS1 LCOR LOC149950 LTBR MAP3K14 MAP6 MAPRE2 METTL17 MORN3 MOS MYEF2 NEBL NGFRAP1 NUFIP2 NUPL1 OLIG3 PBX3 PDE4D PHF21A PIN1 PKN1 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RIPK1 RIPK2 RNF31 RTP5 SCNM1 SIK3 SLC25A48 SLC25A6 SNW1 SPG21 SPOP SRC SSC5D STK3 SYCE1 TANK TBC1D16 TCL1A TEAD4 TFAP4 THAP7 TICAM1 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSSC4 USP7 WAC ZC2HC1C ZFYVE21 ZFYVE26 ZNF124 ZNF20 ZNF417 ZNF440 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF662
Entrez ID		10913	7185
HPRD ID		04974	03418
Ensembl ID		ENSG00000135960	ENSG00000056558
Uniprot IDs		Q9UNE0	Q13077
PDB IDs			3M0D
Enriched GO Terms of Interacting Partners?		Trachea Gland Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Trachea Development Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response Signal Transduction Toll-like Receptor 4 Signaling Pathway Signaling Cell Communication Hair Follicle Development Hair Cycle Process Cellular Response To Tumor Necrosis Factor Hair Cycle Odontogenesis Of Dentin-containing Tooth Toll-like Receptor Signaling Pathway Response To Tumor Necrosis Factor Pattern Recognition Receptor Signaling Pathway Odontogenesis Innate Immune Response-activating Signal Transduction Cellular Response To Stimulus Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Immune System Process Positive Regulation Of Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Apoptotic Process Skin Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Positive Regulation Of Cell-cell Adhesion Cell Death Regulation Of Innate Immune Response Death Negative Regulation Of Glial Cell Apoptotic Process Salivary Gland Cavitation Response To Stimulus Epidermis Development Activation Of Protein Kinase Activity	Cell Death Death Programmed Cell Death Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Intracellular Signal Transduction Positive Regulation Of Cell Death Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Cellular Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Necroptotic Process Regulation Of Transcription, DNA-templated Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of RNA Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Cell Communication Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Modification Process
Tagcloud ?		africans appendages backgrounds casts crown dental ectodermal eurasians fgfr2 fras1 genotyped hair japanese koreans metric morphology naf1 nonsynonymous plaster pleiotropic rs10177996 rs7349332 snp snps strongest teeth thada traits wnt10a	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit
Tagcloud (Difference) ?		africans appendages backgrounds casts crown dental ectodermal eurasians fgfr2 fras1 genotyped hair japanese koreans metric morphology naf1 nonsynonymous plaster pleiotropic rs10177996 rs7349332 snp snps strongest teeth thada traits wnt10a	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit
Tagcloud (Intersection) ?