EDAR and MAP3K14

Number of citations of the paper that reports this interaction (PMID 11035039)
22

Data Source:
HPRD (in vivo)

		EDAR	MAP3K14
Gene Name		ectodysplasin A receptor	mitogen-activated protein kinase kinase kinase 14
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Part Of Cell	Cytosol
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Hair Follicle Development Apoptotic Process Signal Transduction Epidermis Development Cell Differentiation Positive Regulation Of NF-kappaB Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Pigmentation Salivary Gland Cavitation	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Immune Response I-kappaB Kinase/NF-kappaB Signaling Signal Transduction By Phosphorylation T Cell Costimulation NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Mechanical Stimulus
Pathways			Costimulation by the CD28 family CD28 co-stimulation CD28 dependent PI3K/Akt signaling Adaptive Immune System
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		6 interactors: EDA EDARADD MAP3K14 TRAF1 TRAF2 TRAF3	39 interactors: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKAP IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 ZFP91
Entrez ID		10913	9020
HPRD ID		04974	05230
Ensembl ID		ENSG00000135960
Uniprot IDs		Q9UNE0	Q99558
PDB IDs			4DN5 4G3D 4IDT 4IDV
Enriched GO Terms of Interacting Partners?		Trachea Gland Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Trachea Development Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response Signal Transduction Toll-like Receptor 4 Signaling Pathway Signaling Cell Communication Hair Follicle Development Hair Cycle Process Cellular Response To Tumor Necrosis Factor Hair Cycle Odontogenesis Of Dentin-containing Tooth Toll-like Receptor Signaling Pathway Response To Tumor Necrosis Factor Pattern Recognition Receptor Signaling Pathway Odontogenesis Innate Immune Response-activating Signal Transduction Cellular Response To Stimulus Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Immune System Process Positive Regulation Of Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Apoptotic Process Skin Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Positive Regulation Of Cell-cell Adhesion Cell Death Regulation Of Innate Immune Response Death Negative Regulation Of Glial Cell Apoptotic Process Salivary Gland Cavitation Response To Stimulus Epidermis Development Activation Of Protein Kinase Activity	TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Positive Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling NIK/NF-kappaB Signaling Regulation Of Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Fc Receptor Signaling Pathway Defense Response Apoptotic Process Immune System Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Regulation Of Cellular Protein Metabolic Process Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Activation Of Protein Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		africans appendages backgrounds casts crown dental ectodermal eurasians fgfr2 fras1 genotyped hair japanese koreans metric morphology naf1 nonsynonymous plaster pleiotropic rs10177996 rs7349332 snp snps strongest teeth thada traits wnt10a	alternative bcr birc3 called classical conferred dependence driven exclusive hematological ibrutinib insensitive insensitivity insights kappab lymphomas malignancy mantle mcl mutually nf nik profiling refractory sequencing sotrastaurin stratification traf2 transcriptome
Tagcloud (Difference) ?		africans appendages backgrounds casts crown dental ectodermal eurasians fgfr2 fras1 genotyped hair japanese koreans metric morphology naf1 nonsynonymous plaster pleiotropic rs10177996 rs7349332 snp snps strongest teeth thada traits wnt10a	alternative bcr birc3 called classical conferred dependence driven exclusive hematological ibrutinib insensitive insensitivity insights kappab lymphomas malignancy mantle mcl mutually nf nik profiling refractory sequencing sotrastaurin stratification traf2 transcriptome
Tagcloud (Intersection) ?