MPZL1 and EXOSC4

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		MPZL1	EXOSC4
Gene Name		myelin protein zero-like 1	exosome component 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Focal Adhesion Cell Surface	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	Structural Molecule Activity Protein Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding AU-rich Element Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 22881374)
Protein-Protein Interactions		4 interactors: EXOSC4 FHL3 PTPN11 SRC	27 interactors: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LRRC8D MPP6 MPZL1 NEK1 SKIV2L SKIV2L2 SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		9019	54512
HPRD ID		05086	16221
Ensembl ID		ENSG00000197965	ENSG00000178896
Uniprot IDs		A8K5D4 O95297	Q9NPD3
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Platelet-derived Growth Factor Receptor Signaling Pathway T Cell Costimulation Regulation Of Cellular Response To Insulin Stimulus Ephrin Receptor Signaling Pathway Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Integrin-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Progesterone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Abortive Mitotic Cell Cycle Negative Regulation Of Glucocorticoid Secretion Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of MAP Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Bone Development Positive Regulation Of Cell-cell Adhesion Myeloid Cell Differentiation Defense Response Response To Virus Fc Receptor Signaling Pathway Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Regulation Of MAP Kinase Activity Response To Insulin Regulation Of T Cell Activation Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Nuclear MRNA Surveillance Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Podosome Assembly Positive Regulation Of Secretion Cellular Response To Peptide	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Maturation Of 5.8S RRNA RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing DNA Deamination Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome MRNA Export From Nucleus Metabolic Process
Tagcloud ?		amplified antagonism antagonizers dimerization distinguish driving exerted her2 her3 heterodimer heterodimers homodimers intended kinome layers mitogenic myo3a myo3b pinpoint potentiated screen screens sensitization sensitize si sirna trastuzumab unaffected vesicle
Tagcloud (Difference) ?		amplified antagonism antagonizers dimerization distinguish driving exerted her2 her3 heterodimer heterodimers homodimers intended kinome layers mitogenic myo3a myo3b pinpoint potentiated screen screens sensitization sensitize si sirna trastuzumab unaffected vesicle
Tagcloud (Intersection) ?