MPZL1 and DOK7

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		MPZL1	DOK7
Description		myelin protein zero like 1	docking protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane	Nucleoplasm Mitochondrion Plasma Membrane Membrane Neuromuscular Junction Synapse Postsynaptic Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding Lipid Binding Protein Kinase Binding Phosphatidylinositol Binding Signaling Adaptor Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling	Enzyme-linked Receptor Protein Signaling Pathway Neuromuscular Junction Development Positive Regulation Of Rac Protein Signal Transduction Receptor Clustering Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways
Drugs
Diseases			Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1
GWAS		Alzheimer's disease (late onset) ( 22881374) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Calcium levels ( 29403010) Coronary artery disease ( 33020668) Fibrinogen levels ( 28107422) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Spondylosis ( 33332786)
Interacting Genes		10 interacting genes: DOK7 EXOSC4 FBXO7 FHL3 MFF PTPN11 SRC STAT3 TRIM55 TRIM63	8 interacting genes: APPL1 BCAR1 CRK EFEMP2 EFHC1 MPZL1 MUSK YPEL3
Entrez ID		9019	285489
HPRD ID		05086	08744
Ensembl ID		ENSG00000197965	ENSG00000175920
Uniprot IDs		A8K5D4 O95297	A0A1W2PRA3 A0A2R8Y701 Q18PE1 Q8N1M3
PDB IDs		6IGO 6IGT 6IGW
Enriched GO Terms of Interacting Partners?		Regulation Of Glycolytic Process Negative Regulation Of Neutrophil Activation Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Interleukin-6-mediated Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Glycolytic Process Protein Kinase Binding Negative Regulation Of ATP Metabolic Process Neutrophil Activation Protein Targeting To Mitochondrion Astrocyte Differentiation Negative Regulation Of Leukocyte Activation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Activation Immune System Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of ATP Metabolic Process Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Notch Signaling Pathway T Cell Costimulation Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Vasodilation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Canonical NF-kappaB Signal Transduction Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Epidermal Growth Factor Receptor Signaling Pathway Myeloid Cell Development Protein-containing Complex Positive Regulation Of Phosphate Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Protein Localization To Mitochondrion Establishment Of Protein Localization To Organelle ERBB Signaling Pathway Post-translational Protein Modification Signaling Adaptor Activity Response To Interleukin-1 Regulation Of Cellular Component Organization Intestinal Epithelial Cell Migration Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation	Response To Hepatocyte Growth Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Response To Growth Factor Positive Regulation Of Protein Geranylgeranylation Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Neuromuscular Junction Insulin Receptor Signaling Pathway Helper T Cell Diapedesis Cell Surface Receptor Signaling Pathway Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Macropinocytosis Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Ruffle SH3 Domain Binding Cerebellar Neuron Development Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Collagen Fibril Organization Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Growth Regulation Of Cellular Component Organization Macropinosome Elastic Fiber Regulation Of Protein Localization To Membrane Aorta Smooth Muscle Tissue Morphogenesis Diapedesis Positive Regulation Of Pinocytosis Cell Chemotaxis Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Reelin-mediated Signaling Pathway Response To Endothelin Cellular Response To Endothelin Regulation Of Cell-substrate Adhesion Postsynaptic Specialization Assembly Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Synaptic Assembly At Neuromuscular Junction Endothelin Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Early Phagosome Positive Regulation Of Melanin Biosynthetic Process Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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