MPZL1 and FHL3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MPZL1	FHL3
Gene Name		myelin protein zero-like 1	four and a half LIM domains 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Focal Adhesion Cell Surface	Stress Fiber Nucleus Focal Adhesion Z Disc
	Molecular Function	Structural Molecule Activity Protein Binding	Actin Binding Zinc Ion Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling	Muscle Organ Development Actin Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 22881374)
Protein-Protein Interactions		4 interactors: EXOSC4 FHL3 PTPN11 SRC	88 interactors: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP C14orf105 C9orf116 CDC25B CDC42EP1 CNNM3 CORO1A CSF1 CTBP2 DCDC2B E2F8 EFCAB12 EPHA10 EPM2AIP1 FAM154A FAM71C FAM90A1 FBXL18 FHL2 FHL5 FOSL2 GATA2 GCM2 HIPK1 HYAL2 ITGA7 KIRREL2 KLF3 KLF8 KRTAP12-1 KRTAP12-2 KTI12 LASP1 LMO2 LNX1 MAPK1 MED15 MPZL1 MRPL27 MYBPC1 MYBPHL MZF1 NPRL3 P4HA2 PAK7 PATL1 PHC2 PHF21A PLEKHF2 PPIG PTPN6 QRICH1 RAD21 RBM42 RFX3 RFX6 RHEBL1 RNMTL1 SAP30BP SLAIN1 SLC25A46 SLC44A3 SMAD2 SMAD3 SMAD4 SNRPG SREBF2 SRF TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TTLL10 TYK2 TYMSOS UBE2I UBE2Q1 WNK1 YPEL3 ZNF417 ZNF512B ZNRD1
Entrez ID		9019	2275
HPRD ID		05086	09101
Ensembl ID		ENSG00000197965	ENSG00000183386
Uniprot IDs		A8K5D4 O95297	Q13643 Q96C98
PDB IDs			1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?		Platelet-derived Growth Factor Receptor Signaling Pathway T Cell Costimulation Regulation Of Cellular Response To Insulin Stimulus Ephrin Receptor Signaling Pathway Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Integrin-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Progesterone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Abortive Mitotic Cell Cycle Negative Regulation Of Glucocorticoid Secretion Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of MAP Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Bone Development Positive Regulation Of Cell-cell Adhesion Myeloid Cell Differentiation Defense Response Response To Virus Fc Receptor Signaling Pathway Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Regulation Of MAP Kinase Activity Response To Insulin Regulation Of T Cell Activation Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Nuclear MRNA Surveillance Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Podosome Assembly Positive Regulation Of Secretion Cellular Response To Peptide	RNA Metabolic Process Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Assembly Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cellular Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Proliferation Negative Regulation Of RNA Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Cell Death Death Multicellular Organismal Homeostasis Positive Regulation Of Epithelial To Mesenchymal Transition Endoderm Development Negative Regulation Of Cell Growth Embryonic Organ Development Positive Regulation Of Metabolic Process Primary MiRNA Processing Organ Development Apoptotic Process
Tagcloud ?		amplified antagonism antagonizers dimerization distinguish driving exerted her2 her3 heterodimer heterodimers homodimers intended kinome layers mitogenic myo3a myo3b pinpoint potentiated screen screens sensitization sensitize si sirna trastuzumab unaffected vesicle	accompanied adhesion anchorage antiproliferative arrest b1 cip1 downregulated g1 g2 half implicated interfering knockdown lim marked marker member mobility p21 progression regulator sirna suppressed thereby transduction unclear waf1
Tagcloud (Difference) ?		amplified antagonism antagonizers dimerization distinguish driving exerted her2 her3 heterodimer heterodimers homodimers intended kinome layers mitogenic myo3a myo3b pinpoint potentiated screen screens sensitization sensitize si trastuzumab unaffected vesicle	accompanied adhesion anchorage antiproliferative arrest b1 cip1 downregulated g1 g2 half implicated interfering knockdown lim marked marker member mobility p21 progression regulator suppressed thereby transduction unclear waf1
Tagcloud (Intersection) ?		sirna