MED7 and CAB39

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MED7	CAB39
Description		mediator complex subunit 7	calcium binding protein 39
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Regulator Complex Mediator Complex Nuclear Body Core Mediator Complex	Extracellular Region Cytoplasm Cytosol Z Disc Protein-containing Complex Secretory Granule Lumen Extracellular Exosome Serine/threonine Protein Kinase Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Protein Serine/threonine Kinase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Signal Transduction Response To Activity Intracellular Signal Transduction Cellular Hypotonic Response Response To Thyroid Hormone Negative Regulation Of Potassium Ion Transmembrane Transport
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Energy dependent regulation of mTOR by LKB1-AMPK Neutrophil degranulation
Drugs
Diseases
GWAS		Medication use (thyroid preparations) ( 31015401)
Interacting Genes		22 interacting genes: CAB39 CTDP1 DNMT3L ESR1 ESR2 HAUS1 HGS HNF4A IKBKG LZTR1 MED8 MED9 PCBD2 PML RBFOX2 RELA RHOXF2 SREBF1 TRIM15 TRIM29 UBE2I ZSCAN1	13 interacting genes: CEBPA CEP44 GOLGA2 IPO5 MCCD1 MED7 PRKAA1 RSL1D1 SHMT2 STK11 STK24 STRADA STRADB
Entrez ID		9443	51719
HPRD ID		05439	10091
Ensembl ID		ENSG00000155868	ENSG00000135932
Uniprot IDs		O43513 Q6IAZ5	Q9Y376
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	1UPK 1UPL 2WTK 3GNI 4FZA 4FZD 4FZF 4NZW 4O27 8VSU
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nuclear Receptor Activity Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Estrogen Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Estrogen Receptor Activity Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Transcription Coregulator Binding Intracellular Signal Transduction RNA Polymerase II Preinitiation Complex Assembly Zinc Ion Binding Negative Regulation Of Cell Growth Canonical NF-kappaB Signal Transduction Transcription Preinitiation Complex Assembly Regulation Of DNA-binding Transcription Factor Activity Estrogen Response Element Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Enzyme Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Growth Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Suppression Of Viral Release By Host Negative Regulation Of Biosynthetic Process Sequence-specific DNA Binding	Organelle Disassembly Serine/threonine Protein Kinase Complex Regulation Of Protein Metabolic Process Intracellular Protein-containing Complex Activation Of Protein Kinase Activity Negative Regulation Of Translational Initiation Negative Regulation Of Hepatocyte Apoptotic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Protein Kinase Activity G1 To G0 Transition Regulation Of Translational Initiation Macromolecule Metabolic Process Cadherin Binding Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Protein Phosphorylation Positive Regulation Of Kinase Activity Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Protein Modification Process Phosphorylation Regulation Of Protein Localization To Nucleus Protein Export From Nucleus Regulation Of Translation Rescue Of Stalled Ribosome Intracellular Signal Transduction Negative Regulation Of Translation Protein Kinase Activator Activity Carbohydrate Homeostasis Macrophage Differentiation Glucose Homeostasis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Multicellular Organismal-level Homeostasis Centrosome Cycle Negative Regulation Of Glucosylceramide Biosynthetic Process L-allo-threonine Aldolase Activity Regulation Of Type I Interferon-mediated Signaling Pathway Ribosome Disassembly Negative Regulation Of Immune Response Response To Ketone Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Negative Regulation Of Immune System Process Regulation Of Protein Kinase Activity Regulation Of Immune Response
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