KLHL6 and TMPO

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHL6	TMPO
Description		kelch like family member 6	thymopoietin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex	Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Chromosome Cytoplasm Membrane Nuclear Membrane
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	DNA Binding Protein Binding Lamin Binding Cadherin Binding
	Biological Process	Germinal Center Formation Response To Bacterium Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process B Cell Receptor Signaling Pathway
Pathways			RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Youthful appearance (self-reported) ( 32339537)	Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: BYSL CDK2 CRY2 CUL3 FH PPP1R1B SBDS TMPO	27 interacting genes: ABL1 AKAP8L BANF1 CDK1 CEBPA CLK1 CSNK2A1 FXR1 GMCL1 GOLM1 HDAC3 KLHL6 LMNA LMNB1 LMNB2 OGT OIP5 RB1 RNF123 SGTA SGTB SRC SRPK2 STOM SUMO2 USP7 WEE2-AS1
Entrez ID		89857	7112
HPRD ID		10035	01777
Ensembl ID		ENSG00000172578	ENSG00000120802
Uniprot IDs		Q8WZ60	G5E972 P42166 P42167 Q59G12
PDB IDs			1GJJ 1H9E 1H9F 8FN7 8FND 8FNG 8FNH 8FNJ 8FNL 8FNM 8FNN 8FNO 8FNP 8FNQ
Enriched GO Terms of Interacting Partners?		Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasm Macromolecule Metabolic Process RNA Metabolic Process Nucleus DNA-templated Transcription Cell Cycle G1/S Phase Transition Cyclin Binding G1/S Transition Of Mitotic Cell Cycle Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Photoreactive Repair Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Protein Phosphatase Inhibitor Activity Fumarate Metabolic Process Fumarate Hydratase Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Ribosome Biogenesis Positive Regulation Of Chromatin Organization DNA Repair Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cry-Per Complex Regulation Protein Catabolic Process At Postsynapse Cytosol X Chromosome Negative Regulation Of Glucocorticoid Secretion POZ Domain Binding Negative Regulation Of Female Receptivity Mitotic Cell Cycle Phase Transition Regulation Of Sodium-dependent Phosphate Transport Regulation Of Arginine Metabolic Process Polar Microtubule Spindle Pole Cytosolic Ribosome Assembly Cell Cycle Phase Transition Response To Insulin Ribonucleoprotein Complex Biogenesis Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Response To Blue Light	Nuclear Pore Localization Nucleus Organization Negative Regulation Of Gene Expression, Epigenetic Organelle Organization Chromatin Organization Nuclear Envelope Organization Negative Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Chromatin Remodeling Regulation Of Proteasomal Protein Catabolic Process PML Body Nuclear Lamina Negative Regulation Of Macromolecule Biosynthetic Process Protein Localization To Nuclear Envelope Negative Regulation Of Biosynthetic Process Nuclear Matrix Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Structural Constituent Of Nuclear Lamina TRC Complex Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Localization Regulation Of Gene Expression Protein Localization To Organelle Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Nuclear Migration Regulation Of Cellular Localization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Nucleus Localization Cellular Response To Fluid Shear Stress Nucleus Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Nuclear Envelope Rb-E2F Complex Lamin Filament Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process
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