KLHL6 and CRY2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHL6	CRY2
Description		kelch like family member 6	cryptochrome circadian regulator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Speck Cry-Per Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Phosphatase Inhibitor Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding FAD Binding
	Biological Process	Germinal Center Formation Response To Bacterium Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process B Cell Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Protein Import Into Nucleus Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Response To Insulin Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways			Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		Youthful appearance (self-reported) ( 32339537)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Glycemic traits (pleiotropy) ( 31021400) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)
Interacting Genes		8 interacting genes: BYSL CDK2 CRY2 CUL3 FH PPP1R1B SBDS TMPO	53 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 CYSRT1 DELEC1 EZH2 FBXL21P FBXL3 KLHL6 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP19-6 KRTAP4-2 KRTAP5-1 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-8 LMNA MID1 MTUS2 NADK NBPF19 NOTCH2NLA NPAS2 PDE9A PER1 PER2 PER3 PICK1 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGER4 SBK3 SDCBP2 STK11 TIMELESS TRAF1 TRAF2 TTC1 VWC2 XRN2 ZBTB42
Entrez ID		89857	1408
HPRD ID		10035	07226
Ensembl ID		ENSG00000172578	ENSG00000121671
Uniprot IDs		Q8WZ60	A0A0D2X7Z3 A2I2P1 Q49AN0
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasm Macromolecule Metabolic Process RNA Metabolic Process Nucleus DNA-templated Transcription Cell Cycle G1/S Phase Transition Cyclin Binding G1/S Transition Of Mitotic Cell Cycle Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Photoreactive Repair Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Protein Phosphatase Inhibitor Activity Fumarate Metabolic Process Fumarate Hydratase Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Ribosome Biogenesis Positive Regulation Of Chromatin Organization DNA Repair Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cry-Per Complex Regulation Protein Catabolic Process At Postsynapse Cytosol X Chromosome Negative Regulation Of Glucocorticoid Secretion POZ Domain Binding Negative Regulation Of Female Receptivity Mitotic Cell Cycle Phase Transition Regulation Of Sodium-dependent Phosphate Transport Regulation Of Arginine Metabolic Process Polar Microtubule Spindle Pole Cytosolic Ribosome Assembly Cell Cycle Phase Transition Response To Insulin Ribonucleoprotein Complex Biogenesis Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Response To Blue Light	Intermediate Filament Photoperiodism Regulation Of Circadian Rhythm Rhythmic Process Entrainment Of Circadian Clock By Photoperiod Keratin Filament Entrainment Of Circadian Clock Cytosol Circadian Regulation Of Gene Expression Circadian Rhythm Transcription Corepressor Binding Identical Protein Binding Response To Light Stimulus Response To Radiation Protein Phosphatase Type 2A Complex CLOCK-BMAL Transcription Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Binding Protein Phosphatase Regulator Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Thioesterase Binding Meiotic Sister Chromatid Cohesion E-box Binding Response To Redox State G1 To G0 Transition
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