KLHL6 and SBDS

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		KLHL6	SBDS
Description		kelch like family member 6	SBDS ribosome maturation factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Binding Protein Binding Microtubule Binding RRNA Binding Ribosome Binding
	Biological Process	Germinal Center Formation Response To Bacterium Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process B Cell Receptor Signaling Pathway	Inner Cell Mass Cell Proliferation Hematopoietic Progenitor Cell Differentiation RRNA Processing Mitotic Spindle Organization Bone Mineralization Leukocyte Chemotaxis Ribosome Biogenesis Cytosolic Ribosome Assembly Bone Marrow Development
Pathways
Drugs
Diseases			Shwachman-Diamond syndrome (SDS) Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Youthful appearance (self-reported) ( 32339537)
Interacting Genes		8 interacting genes: BYSL CDK2 CRY2 CUL3 FH PPP1R1B SBDS TMPO	10 interacting genes: ACD CEBPA CLN3 EFL1 KLHL6 LMNA POT1 RNF2 TERF1 TERF2IP
Entrez ID		89857	51119
HPRD ID		10035	07393
Ensembl ID		ENSG00000172578	ENSG00000126524
Uniprot IDs		Q8WZ60	A0A0S2Z5I7 Q9Y3A5
PDB IDs			2KDO 2L9N 5AN9 5ANB 5ANC 6QKL
Enriched GO Terms of Interacting Partners?		Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasm Macromolecule Metabolic Process RNA Metabolic Process Nucleus DNA-templated Transcription Cell Cycle G1/S Phase Transition Cyclin Binding G1/S Transition Of Mitotic Cell Cycle Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Photoreactive Repair Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Protein Phosphatase Inhibitor Activity Fumarate Metabolic Process Fumarate Hydratase Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Ribosome Biogenesis Positive Regulation Of Chromatin Organization DNA Repair Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cry-Per Complex Regulation Protein Catabolic Process At Postsynapse Cytosol X Chromosome Negative Regulation Of Glucocorticoid Secretion POZ Domain Binding Negative Regulation Of Female Receptivity Mitotic Cell Cycle Phase Transition Regulation Of Sodium-dependent Phosphate Transport Regulation Of Arginine Metabolic Process Polar Microtubule Spindle Pole Cytosolic Ribosome Assembly Cell Cycle Phase Transition Response To Insulin Ribonucleoprotein Complex Biogenesis Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Response To Blue Light	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of Chromosome Organization DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Macromolecule Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere Organelle Organization Negative Regulation Of Macromolecule Metabolic Process Telomeric D-loop Disassembly Positive Regulation Of DNA Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of Metabolic Process Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Regulation Of Organelle Organization Chromosome Negative Regulation Of Cellular Component Organization Telomere Maintenance In Response To DNA Damage Chromosome Organization Nuclear Body Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Organelle Organization
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