KLHL6 and FH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHL6	FH
Description		kelch like family member 6	fumarate hydratase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Site Of Double-strand Break Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Catalytic Activity Fumarate Hydratase Activity Protein Binding Lyase Activity Histone Binding
	Biological Process	Germinal Center Formation Response To Bacterium Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process B Cell Receptor Signaling Pathway	Urea Cycle Regulation Of Arginine Metabolic Process Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Arginine Metabolic Process DNA Damage Response Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			Citric acid cycle (TCA cycle) Mitochondrial protein degradation
Drugs
Diseases			Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency Multiple cutaneous and uterine leiomyomata Renal cell carcinoma
GWAS		Youthful appearance (self-reported) ( 32339537)	Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: BYSL CDK2 CRY2 CUL3 FH PPP1R1B SBDS TMPO	18 interacting genes: CCDC102B CCDC57 CCNDBP1 CSTPP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 OGT PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19
Entrez ID		89857	2271
HPRD ID		10035	00652
Ensembl ID		ENSG00000172578	ENSG00000091483
Uniprot IDs		Q8WZ60	A0A0S2Z4C3 P07954
PDB IDs			3E04 5D6B 5UPP 6EBT 6V8F 6VBE 7LUB
Enriched GO Terms of Interacting Partners?		Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasm Macromolecule Metabolic Process RNA Metabolic Process Nucleus DNA-templated Transcription Cell Cycle G1/S Phase Transition Cyclin Binding G1/S Transition Of Mitotic Cell Cycle Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Photoreactive Repair Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Protein Phosphatase Inhibitor Activity Fumarate Metabolic Process Fumarate Hydratase Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Ribosome Biogenesis Positive Regulation Of Chromatin Organization DNA Repair Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cry-Per Complex Regulation Protein Catabolic Process At Postsynapse Cytosol X Chromosome Negative Regulation Of Glucocorticoid Secretion POZ Domain Binding Negative Regulation Of Female Receptivity Mitotic Cell Cycle Phase Transition Regulation Of Sodium-dependent Phosphate Transport Regulation Of Arginine Metabolic Process Polar Microtubule Spindle Pole Cytosolic Ribosome Assembly Cell Cycle Phase Transition Response To Insulin Ribonucleoprotein Complex Biogenesis Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Response To Blue Light	Non-canonical Inflammasome Complex Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?