KCNK17 and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		KCNK17	VKORC1
Description		potassium two pore domain channel subfamily K member 17	vitamin K epoxide reductase complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development
Pathways		TWIK-related alkaline pH activated K+ channel (TALK) Phase 4 - resting membrane potential	Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases			Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		1 interacting genes: VKORC1	93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		89822	79001
HPRD ID		09566	10540
Ensembl ID		ENSG00000124780	ENSG00000167397
Uniprot IDs		Q96T54	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs			6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Tonic Smooth Muscle Contraction Artery Smooth Muscle Contraction Regulation Of Cilium Beat Frequency BBSome Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Vascular Associated Smooth Muscle Contraction Striatum Development Leptin-mediated Signaling Pathway Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Quinone Binding Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Regulation Of Response To Food Pigment Granule Localization Establishment Of Melanosome Localization Melanosome Localization Response To Leptin Brain Morphogenesis Melanosome Transport Pigment Granule Transport Regulation Of Appetite Sperm Axoneme Assembly Positive Regulation Of Coagulation Vasoconstriction Positive Regulation Of Multicellular Organism Growth Regulation Of Response To Nutrient Levels Golgi To Plasma Membrane Protein Transport Regulation Of Cilium Movement Photoreceptor Cell Maintenance Stereocilium Smooth Muscle Contraction Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Vasodilation Axoneme Assembly Animal Organ Development Ciliary Membrane Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Regulation Of Multicellular Organism Growth Microvillus Hippocampus Development Bone Development Positive Regulation Of Multicellular Organismal Process	Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport
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