NAV1 and TBC1D4

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		NAV1	TBC1D4
Gene Name		neuron navigator 1	TBC1 domain family, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule	Cytoplasm Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function		Rab GTPase Activator Activity
	Biological Process	Microtubule Bundle Formation Neuron Migration	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Positive Regulation Of Rab GTPase Activity Cellular Response To Insulin Stimulus Membrane Organization
Pathways			Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Diabetic retinopathy ( 23562823) Heart failure ( 20445134)
Protein-Protein Interactions		6 interactors: APC APP GCC1 KRT31 MAPRE1 TBC1D4	14 interactors: AKT1 CDK5RAP2 EP400 FAM208A KIAA1551 NAV1 NFAT5 PIN1 RBM12 TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		89796	9882
HPRD ID		10113	18164
Ensembl ID		ENSG00000134369	ENSG00000136111
Uniprot IDs		Q8NEY1	O60343
PDB IDs			3QYB
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule Polymerization Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Or Depolymerization Synaptic Growth At Neuromuscular Junction Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule-based Process Collateral Sprouting In Absence Of Injury Positive Regulation Of Microtubule Plus-end Binding Negative Regulation Of Odontogenesis Regulation Of Organelle Organization Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Binding Cell Cycle Phase Transition Epidermis Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Protein Localization To Microtubule Negative Regulation Of Vesicle Fusion Neuron Remodeling Mitotic Nuclear Division Regulation Of Protein Complex Assembly Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Negative Regulation Of Proteolysis Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Protein Processing Negative Regulation Of Microtubule Polymerization Vesicle-mediated Transport Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Copper Ion Homeostasis Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Cytoskeleton Copper Ion Homeostasis Suckling Behavior Protein Targeting To Golgi Regulation Of Cell Cycle Process Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition Microtubule Bundle Formation Positive Regulation Of Mitochondrion Organization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process 5-methylcytosine Catabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Organelle Organization Peptidyl-amino Acid Modification Negative Regulation Of Phosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vitellogenesis Regulation Of Cell Cycle Process Organelle Organization G2/M Transition Of Mitotic Cell Cycle Cytosine Metabolic Process Regulation Of Neuron Differentiation Liver Morphogenesis Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Centriole Replication Hematopoietic Stem Cell Homeostasis Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of MAPK Cascade Response To UV-A Activation-induced Cell Death Of T Cells Oxidative DNA Demethylation Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Regulation Of Neurogenesis Myeloid Progenitor Cell Differentiation Cytoplasm Organization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Generation Of Neurons Cellular Response To Insulin Stimulus Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity
Tagcloud ?		14d 7d actived bilatral contralateral drg dropped fluorocitrate fluorocitric glial hind hindpaws hyperalgesia hypersensitivity intrathecal ipsilateral l5 ligated mip mirror paw paws sectioned sham sides snl threshold weighing withdrawal	amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand
Tagcloud (Difference) ?		14d 7d actived bilatral contralateral drg dropped fluorocitrate fluorocitric glial hind hindpaws hyperalgesia hypersensitivity intrathecal ipsilateral l5 ligated mip mirror paw paws sectioned sham sides snl threshold weighing withdrawal	amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand
Tagcloud (Intersection) ?