NAV1 and GCC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NAV1	GCC1
Description		neuron navigator 1	GRIP and coiled-coil domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Axon Initial Segment	Golgi Trans Cisterna Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Microtubule Bundle Formation Neuron Migration Nervous System Development Neurogenesis Cell Differentiation
Pathways			Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29273807 25673413 26961502 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Calcific aortic valve stenosis ( 32141789) Celiac disease ( 23936387) Diastolic blood pressure ( 30578418) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Sepsis (hospital admission) ( 32592749) Sleep duration (short sleep) ( 30846698) Waist circumference ( 25673412)	Feeling worry ( 29500382) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Medication adherence in chronic diseases ( 25317111) Refractive error ( 32231278) Type 2 diabetes ( 22158537 26818947 30718926)
Interacting Genes		10 interacting genes: APC APP DDIT4L GCC1 KIFAP3 KRT31 MAPRE1 PRIMPOL RSRC2 TBC1D4	66 interacting genes: ABI2 AMOTL2 APP ARL1 ATF4 ATN1 BIRC2 BRCA1 C1orf94 CCDC33 CCDC85B CEP57 CEP70 COIL CPSF7 DISC1 DNAJA3 DRC4 FAM83A FBF1 FBXO28 FIGNL1 FOSL1 GLI1 GOLGA2 GTF2I HDX ICA1L IKBKG ITSN1 KATNAL1 KDM1A KIAA0753 KIAA1217 KIF5B LCA5 LZTS2 MCRS1 MED4 MEOX1 MID2 NAB2 NAV1 NECAB2 NINL OIP5 PAK5 PPP1R18 PPP1R27 PRPF18 RUNX1 SMARCA2 SMARCD1 SPOP TFIP11 TLE5 TP53BP2 TRIM29 TRIM50 TSC1 USHBP1 UTP14C XIAP ZC4H2 ZFP90 ZNF276
Entrez ID		89796	79571
HPRD ID		10113	07599
Ensembl ID		ENSG00000134369	ENSG00000179562
Uniprot IDs		A0A8I5KSE4 Q8NEY1	A4D0Z4 Q96CN9
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule Plus-end Binding Golgi Apparatus Protein Serine/threonine Kinase Binding Cytoplasmic Microtubule Microtubule Cytoskeleton Negative Regulation Of Microtubule Polymerization Or Depolymerization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Localization To Astral Microtubule Positive Regulation Of Calcium-dependent Cell-cell Adhesion Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Supramolecular Fiber Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Localization To Mitotic Spindle Mitotic Spindle Astral Microtubule End Cortical Microtubule Cytoskeleton Protein Localization To Spindle Microtubule Kinesin II Complex	Identical Protein Binding Protein Binding Cytoskeleton Microtubule Centrosome Microtubule Severing Transcription Coactivator Activity Microtubule-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of DNA Repair Microtubule Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process P53 Binding Microtubule Severing ATPase Activity Regulation Of Primary Metabolic Process Lens Fiber Cell Morphogenesis Ciliary Basal Body Regulation Of Cellular Response To Stress Regulation Of Double-strand Break Repair Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Manganese Ion Spindle Pole Cytoplasm Organization Microtubule Cytoskeleton Organization Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Spermatid Development
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