CCNC and SPAG8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCNC	SPAG8
Description		cyclin C	sperm associated antigen 8
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Mediator Complex CKM Complex	Acrosomal Vesicle Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Spindle Cytosol Cytoskeleton Axonemal Microtubule Cilium Membrane Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Identical Protein Binding	Protein Binding Microtubule Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Spermatogenesis Single Fertilization Cell Differentiation Flagellated Sperm Motility Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Daytime nap ( 33568662) Erectile dysfunction ( 30297428) Longevity (100 years and older) ( 33948810) Refractive error ( 32231278)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		79 interacting genes: ASH2L BLOC1S2 BTBD2 CCHCR1 CCNH CDK3 CDK8 CDKN2B CFAP53 CKS1B CRX DYDC1 ERCC3 ESR2 FAM161A FAM50B FAM90A1 FOXP2 FOXR2 GADD45GIP1 GLYR1 GOLGA2 GPC4 HACE1 HSPB1 ISY1 KRT13 KRT15 KRT16 KRT27 KRT31 KRT34 LCN2 LZTS2 MBD3 MBIP MCM2 MED8 MEOX2 MGST3 MYO15B NDUFB7 NEFL NMNAT1 NRBF2 PAX5 PLEKHO2 PLIN3 PNMA5 POU6F2 PRPF18 PUF60 RB1 RBM41 REL RFC5 RIBC1 RPA2 RUSC1 SERTAD3 SHC3 SPAG8 TADA3 TCEANC TEPSIN TEX12 TP63 TRAF3IP3 TRIM39 TRIM54 UBE2K VHL VTA1 ZFP90 ZNF18 ZNF426 ZNF620 ZNF688 ZNF792	87 interacting genes: ACTMAP ARMC5 B9D2 BATF2 CARM1 CCDC120 CCNC CDC23 CFP CSTF2 CSTF2T CTAG1A CTAG1B DMRT3 DOK3 DTX2 DYNLL2 EGFL7 FAM168B GIGYF1 GLYCTK GPSM3 HR INCA1 INTS11 JMJD4 KDM3B KLHL32 KRT34 KRTAP10-8 KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP26-1 KRTAP3-1 KRTAP6-2 KRTAP7-1 LASP1 MEOX1 METTL15 MGAT5B NEDD4L NHLRC4 NSD3 NUDT21 PATZ1 PEF1 PFDN5 PHF1 PITX1 PLA2G10 PRMT1 PRMT2 PRMT5 PRR35 RAN RBP3 RIPK4 RNF125 RUSC1 SERGEF SMUG1 SMYD1 SNRPB SNRPC SYNGAP1 TEKT3 TEKT5 TENT5B TRIB3 TRIM42 TSC1 TTC23 UBAP2 UBQLN1 UBQLN4 USP2 VPS37C YPEL3 ZBTB32 ZIC1 ZNF34 ZNF581
Entrez ID		892	26206
HPRD ID		00456	12039
Ensembl ID		ENSG00000112237	ENSG00000137098
Uniprot IDs		E5RFK5 G5E954 P24863 Q7Z4L3	A0A140VJV0 Q99932
PDB IDs		3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41 6TPA 6Y0A 8TQ2 8TQC 8TQW 9H8C 9H8S	7UNG 8J07
Enriched GO Terms of Interacting Partners?		Nucleus Intermediate Filament Organization Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament DNA Binding Generation Of Catalytic Spliceosome For Second Transesterification Step Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Chromatin Cytoskeleton Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Structural Molecule Activity Axonemal A Tubule Inner Sheath Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Epithelial Cell Differentiation Epidermis Development Regulation Of Metabolic Process Importin-alpha Family Protein Binding Morphogenesis Of An Epithelium Regulation Of Mitotic Cell Cycle Phase Transition DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Phase Transition Anterograde Axonal Transport	Intermediate Filament Protein-arginine N-methyltransferase Activity Protein Binding Histone Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Methylation Methyltransferase Activity Methylosome Protein Methylation Histone Arginine N-methyltransferase Activity MRNA Cleavage And Polyadenylation Specificity Factor Complex Keratin Filament Histone H3K9me/H3K9me2 Demethylase Activity Histone H3 Methyltransferase Activity Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Macromolecule Methylation
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