CCNC and CDK3

Number of citations of the paper that reports this interaction (PMID 15084261)
42

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CCNC	CDK3
Gene Name		cyclin C	cyclin-dependent kinase 3
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase II, Holoenzyme Mediator Complex
	Molecular Function	Protein Binding Protein Kinase Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Mitotic Nuclear Division Cell Proliferation G0 To G1 Transition Cell Division Regulation Of Cell Cycle
Pathways		Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: CCNH CDK3 CDK8 CRX CTD DYDC1 ERCC3 ESR1 ESR2 FOXP2 GLYR1 GOLGA2 KRT13 KRT15 KRT31 LZTS2 MBIP MBP MCM2 MED8 MEOX2 MGST3 NEFL NMNAT1 PBXIP1 PNMA5 PUF60 RB1 TADA3 TP63 TRIM39 ZNF18	18 interactors: APP CABLES1 CABLES2 CCNA2 CCNC CCNE1 CCNE2 CDC37 CDKN1A CDKN1B CDKN3 E2F1 E2F2 E2F3 KIR3DL1 NEDD4L PPARA RB1
Entrez ID		892	1018
HPRD ID		00456	00446
Ensembl ID		ENSG00000112237	ENSG00000250506
Uniprot IDs		E5RFK5 P24863 Q7Z4L3	Q00526
PDB IDs		3RGF 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L	1LFN
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Intracellular Estrogen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Female Genitalia Development Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Prostate Gland Epithelium Morphogenesis Mitotic Cell Cycle Process Prostate Gland Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Development G1/S Transition Of Mitotic Cell Cycle Genitalia Development Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Neuron Death Prostate Gland Development Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Vagina Development Uterus Development Negative Regulation Of Gene Expression Cell Cycle Chromosome Organization Chromatin Organization Cell Cycle Process Epithelial Cell Differentiation Involved In Prostate Gland Development Cell Death Death Nucleotide-excision Repair, DNA Damage Removal Regulation Of Gene Expression	Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Checkpoint Cell Division Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Regulation Of Mitotic Cell Cycle DNA-templated Transcription, Initiation Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Transcription, DNA-templated Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Lens Fiber Cell Apoptotic Process Notch Signaling Pathway Regulation Of Gene Expression Cell Cycle Arrest Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Signaling Negative Regulation Of Mitotic Cell Cycle
Tagcloud ?		aa ascorbic ccnd1 cyp7a1 den diethylnitrosamine drinking enhances ercc expressions fed hepatectomy hepatocellular hepatocytes icr initiation intraperitoneally ka kojic ppm proliferating proliferative removed sacrificed subjected surviving thirds week weights	3h adenovirus augmented beta brdu cyclin d2 d3 dedifferentiation exit g0 g1 hypothesized incorporation inducing islets ki67 pancreatic prb quiescence quiescent rat recover regeneration replace staining thymidine transduced tunel
Tagcloud (Difference) ?		aa ascorbic ccnd1 cyp7a1 den diethylnitrosamine drinking enhances ercc expressions fed hepatectomy hepatocellular hepatocytes icr initiation intraperitoneally ka kojic ppm proliferating proliferative removed sacrificed subjected surviving thirds week weights	3h adenovirus augmented beta brdu cyclin d2 d3 dedifferentiation exit g0 g1 hypothesized incorporation inducing islets ki67 pancreatic prb quiescence quiescent rat recover regeneration replace staining thymidine transduced tunel
Tagcloud (Intersection) ?