CCNC and FOXP2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CCNC	FOXP2
Gene Name		cyclin C	forkhead box P2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase II, Holoenzyme Mediator Complex	Nucleus
	Molecular Function	Protein Binding Protein Kinase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesenchymal Cell Proliferation Transcription, DNA-templated Skeletal Muscle Tissue Development Post-embryonic Development Cerebellum Development Caudate Nucleus Development Putamen Development Cerebral Cortex Development Growth Vocal Learning Camera-type Eye Development Negative Regulation Of Transcription, DNA-templated Lung Alveolus Development Smooth Muscle Tissue Development Righting Reflex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Pathways		Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Crohn's disease ( 22936669)
Protein-Protein Interactions		32 interactors: CCNH CDK3 CDK8 CRX CTD DYDC1 ERCC3 ESR1 ESR2 FOXP2 GLYR1 GOLGA2 KRT13 KRT15 KRT31 LZTS2 MBIP MBP MCM2 MED8 MEOX2 MGST3 NEFL NMNAT1 PBXIP1 PNMA5 PUF60 RB1 TADA3 TP63 TRIM39 ZNF18	13 interactors: AES CCNC CTBP1 CTBP2 FAM124A FOXP1 FOXP4 MAPK3 PIN1 RPIA SDCBP SP4 TSACC
Entrez ID		892	93986
HPRD ID		00456	05611
Ensembl ID		ENSG00000112237	ENSG00000128573
Uniprot IDs		E5RFK5 P24863 Q7Z4L3	B7ZLK5 O15409 Q8N6B5 Q8N6B6
PDB IDs		3RGF 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L	2A07 2AS5
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Intracellular Estrogen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Female Genitalia Development Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Prostate Gland Epithelium Morphogenesis Mitotic Cell Cycle Process Prostate Gland Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Development G1/S Transition Of Mitotic Cell Cycle Genitalia Development Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Neuron Death Prostate Gland Development Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Vagina Development Uterus Development Negative Regulation Of Gene Expression Cell Cycle Chromosome Organization Chromatin Organization Cell Cycle Process Epithelial Cell Differentiation Involved In Prostate Gland Development Cell Death Death Nucleotide-excision Repair, DNA Damage Removal Regulation Of Gene Expression	Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Lung Goblet Cell Differentiation Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Lung Secretory Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter White Fat Cell Differentiation Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Viral Genome Replication Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Binding Negative Regulation Of Biosynthetic Process Regulation Of Histone Acetylation Positive Regulation Of Metabolic Process Biosynthetic Process Negative Regulation Of Protein Binding Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Lung Epithelial Cell Differentiation Lung Cell Differentiation Lung Epithelium Development Interleukin-21 Secretion Negative Regulation Of Apolipoprotein Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Positive Regulation Of Histone Modification Regulation Of Organelle Organization Axon Guidance Regulation Of Signal Transduction Response To Interleukin-1 Positive Regulation Of Organelle Organization
Tagcloud ?		aa ascorbic ccnd1 cyp7a1 den diethylnitrosamine drinking enhances ercc expressions fed hepatectomy hepatocellular hepatocytes icr initiation intraperitoneally ka kojic ppm proliferating proliferative removed sacrificed subjected surviving thirds week weights	20p12 21q22 22q13 42e 6p21 7q31 aif1 ancestry cd crohn cumulative ep300 european exerted genotyped gwas ifngr2 intergenic likelihood loci macrod2 rbx1 representing rs4820425 southern spain suggestive top undiscovered
Tagcloud (Difference) ?		aa ascorbic ccnd1 cyp7a1 den diethylnitrosamine drinking enhances ercc expressions fed hepatectomy hepatocellular hepatocytes icr initiation intraperitoneally ka kojic ppm proliferating proliferative removed sacrificed subjected surviving thirds week weights	20p12 21q22 22q13 42e 6p21 7q31 aif1 ancestry cd crohn cumulative ep300 european exerted genotyped gwas ifngr2 intergenic likelihood loci macrod2 rbx1 representing rs4820425 southern spain suggestive top undiscovered
Tagcloud (Intersection) ?