CCNC and VTA1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CCNC	VTA1
Name		cyclin C	vesicle trafficking 1
Structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Mediator Complex CKM Complex	Nucleoplasm Cytoplasm Endosome Multivesicular Body Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Identical Protein Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Protein Transport Macroautophagy Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Sorting Pathway ESCRT III Complex Disassembly
Pathways		PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
GWAS		Daytime nap ( 33568662 ) Erectile dysfunction ( 30297428 ) Longevity (100 years and older) ( 33948810 ) Refractive error ( 32231278 )	Chronic obstructive pulmonary disease ( 30804561 ) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444 ) FEV1 ( 30804560 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Peak expiratory flow ( 30804560 ) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578 ) Retinal vascular caliber ( 21060863 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 )
Interacting Genes		79 interacting genes: ASH2L BLOC1S2 BTBD2 CCHCR1 CCNH CDK3 CDK8 CDKN2B CFAP53 CKS1B CRX DYDC1 ERCC3 ESR2 FAM161A FAM50B FAM90A1 FOXP2 FOXR2 GADD45GIP1 GLYR1 GOLGA2 GPC4 HACE1 HSPB1 ISY1 KRT13 KRT15 KRT16 KRT27 KRT31 KRT34 LCN2 LZTS2 MBD3 MBIP MCM2 MED8 MEOX2 MGST3 MYO15B NDUFB7 NEFL NMNAT1 NRBF2 PAX5 PLEKHO2 PLIN3 PNMA5 POU6F2 PRPF18 PUF60 RB1 RBM41 REL RFC5 RIBC1 RPA2 RUSC1 SERTAD3 SHC3 SPAG8 TADA3 TCEANC TEPSIN TEX12 TP63 TRAF3IP3 TRIM39 TRIM54 UBE2K VHL VTA1 ZFP90 ZNF18 ZNF426 ZNF620 ZNF688 ZNF792	22 interacting genes: APP BEX3 CBS CCNC CDK4 CHMP1A CHMP5 DPPA2 ERBB3 KCTD13 KLHL12 LYST MAGEA11 MBIP NBR1 NECAB2 RABAC1 RPIA SNCA TEAD4 ZBTB16 ZNRD2
Entrez ID		892	51534
HPRD ID		00456	09855
Ensembl ID		ENSG00000112237	ENSG00000009844
Uniprot IDs		E5RFK5 G5E954 P24863 Q7Z4L3	A0A087WY55 Q9NP79
PDB IDs		3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41 6TPA 6Y0A 8TQ2 8TQC 8TQW 9H8C 9H8S	2LXL 2LXM 4TXP 4TXQ 4TXR 4U7E
GO Terms Enriched among Interactors		Nucleus Intermediate Filament Organization Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament DNA Binding Generation Of Catalytic Spliceosome For Second Transesterification Step Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Chromatin Cytoskeleton Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Structural Molecule Activity Axonemal A Tubule Inner Sheath Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Epithelial Cell Differentiation Epidermis Development Regulation Of Metabolic Process Importin-alpha Family Protein Binding Morphogenesis Of An Epithelium Regulation Of Mitotic Cell Cycle Phase Transition DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Phase Transition Anterograde Axonal Transport	Identical Protein Binding Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Regulation Of MAPK Cascade ESCRT III Complex Viral Budding From Plasma Membrane Amphisome Membrane Lysosomal Membrane Organization Vesicle Fusion With Vacuole ESCRT III Complex Disassembly ESCRT Complex Disassembly Multivesicular Body-lysosome Fusion Protein Domain Specific Binding Presynapse Regulation Of Neurotransmitter Uptake Late Endosome To Lysosome Transport Kinetochore Microtubule Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Amyloid Fibril Formation Cytoplasm Cellular Response To Copper Ion Lysosomal Transport Vesicle Organization Plasma Membrane Repair Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Budding Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell Midbody Abscission Regulation Of Receptor Recycling Microglial Cell Activation Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Synaptic Transmission Leukocyte Activation Involved In Inflammatory Response Multivesicular Body Organization Multivesicular Body Assembly Regulation Of Spindle Assembly Response To Copper Ion Regulation Of JNK Cascade Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding