CCNC and NEFL

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		CCNC	NEFL
Name		cyclin C	neurofilament light chain
Structure			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Mediator Complex CKM Complex	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Neurofilament Axon Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Intermediate Filament Cytoskeleton Schaffer Collateral - CA1 Synapse Cholinergic Synapse Postsynaptic Intermediate Filament Cytoskeleton Presynaptic Intermediate Filament Cytoskeleton Axon Cytoplasm
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Identical Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Tubulin Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
	Biological Process	Regulation Of Transcription By RNA Polymerase II G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Microtubule Cytoskeleton Organization Axonogenesis Anterograde Axonal Transport Retrograde Axonal Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axonal Transport Of Mitochondrion Spinal Cord Development Hippocampus Development Cerebral Cortex Development Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Intermediate Filament Polymerization Or Depolymerization Intermediate Filament Organization Intermediate Filament Bundle Assembly Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone Neurofilament Cytoskeleton Organization Regulation Of Synapse Maturation Motor Neuron Apoptotic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Postsynaptic Intermediate Filament Cytoskeleton Organization Response To Sodium Arsenite Response To Acrylamide Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Diseases		None	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Daytime nap ( 33568662 ) Erectile dysfunction ( 30297428 ) Longevity (100 years and older) ( 33948810 ) Refractive error ( 32231278 )	Fear of minor pain ( 28701861 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 )
Interacting Genes		79 interacting genes: ASH2L BLOC1S2 BTBD2 CCHCR1 CCNH CDK3 CDK8 CDKN2B CFAP53 CKS1B CRX DYDC1 ERCC3 ESR2 FAM161A FAM50B FAM90A1 FOXP2 FOXR2 GADD45GIP1 GLYR1 GOLGA2 GPC4 HACE1 HSPB1 ISY1 KRT13 KRT15 KRT16 KRT27 KRT31 KRT34 LCN2 LZTS2 MBD3 MBIP MCM2 MED8 MEOX2 MGST3 MYO15B NDUFB7 NEFL NMNAT1 NRBF2 PAX5 PLEKHO2 PLIN3 PNMA5 POU6F2 PRPF18 PUF60 RB1 RBM41 REL RFC5 RIBC1 RPA2 RUSC1 SERTAD3 SHC3 SPAG8 TADA3 TCEANC TEPSIN TEX12 TP63 TRAF3IP3 TRIM39 TRIM54 UBE2K VHL VTA1 ZFP90 ZNF18 ZNF426 ZNF620 ZNF688 ZNF792	55 interacting genes: BRD7 CCDC13 CCDC172 CCDC33 CCNC CDK5RAP2 CEP57L1 CHD3 DES DSCAM ENKD1 FXR1 GFAP GOLGA2 GORASP1 GRIN1 HGS ITSN1 KDM1A KIFC3 KLC3 KRT13 KRT15 KRT18 MAP2 MTMR2 MTUS2 MYO15B MYO5A NDN NEFH NEIL3 NEK6 NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 RBM11 SHANK3 SKIL SMYD1 SPTAN1 TERF1 TEX11 TRIM55 TRIM63 TSC1 TXLNB USHBP1 USP2 VIM YWHAG
Entrez ID		892	4747
HPRD ID		00456	01206
Ensembl ID		ENSG00000112237	ENSG00000277586
Uniprot IDs		E5RFK5 G5E954 P24863 Q7Z4L3	P07196
PDB IDs		3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41 6TPA 6Y0A 8TQ2 8TQC 8TQW 9H8C 9H8S	Not available
GO Terms Enriched among Interactors		Nucleus Intermediate Filament Organization Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament DNA Binding Generation Of Catalytic Spliceosome For Second Transesterification Step Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Chromatin Cytoskeleton Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Structural Molecule Activity Axonemal A Tubule Inner Sheath Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Epithelial Cell Differentiation Epidermis Development Regulation Of Metabolic Process Importin-alpha Family Protein Binding Morphogenesis Of An Epithelium Regulation Of Mitotic Cell Cycle Phase Transition DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Phase Transition Anterograde Axonal Transport	Cytoskeleton Microtubule Microtubule Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Cytoplasm Intermediate Filament Organization Organelle Organization Centrosome Structural Constituent Of Cytoskeleton Intermediate Filament Cell Projection Microtubule-based Process Regulation Of Nervous System Development Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Neuron Projection Centrosome Cycle Intermediate Filament Cytoskeleton Regulation Of Neurogenesis Supramolecular Fiber Organization Regulation Of Developmental Process Regulation Of Microtubule Polymerization Regulation Of Neuron Projection Development Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurogenesis Plasma Membrane Bounded Cell Projection Organization Scaffold Protein Binding Dendritic Spine Cell Projection Organization Microtubule Organizing Center Organization Gamma-tubulin Binding Protein Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Nervous System Development Regulation Of Cell Development Regulation Of Cell Projection Organization Microtubule Organizing Center Regulation Of Cell Differentiation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Organelle Organization Regulation Of Organelle Transport Along Microtubule Kinesin Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Protein-containing Complex Assembly Organelle Assembly Calmodulin Binding