NKAP and DHX15

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		NKAP	DHX15
Gene Name		NFKB activating protein	DEAH (Asp-Glu-Ala-His) box helicase 15
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Nucleoplasm U12-type Spliceosomal Complex Nucleolus Cytoplasm U2-type Post-mRNA Release Spliceosomal Complex
	Molecular Function	Chromatin Binding Protein Binding Chromatin DNA Binding Poly(A) RNA Binding	RNA Helicase Activity Double-stranded RNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Notch Signaling Pathway Stem Cell Maintenance Granulocyte Differentiation T Cell Differentiation In Thymus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Alpha-beta T Cell Differentiation Hematopoietic Stem Cell Proliferation	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS			Myopia (pathological) ( 23049088)
Protein-Protein Interactions		18 interactors: BUB3 CEP70 DDX41 DHX15 DHX8 FAM124A FRA10AC1 LUC7L2 PCBP2 PPIG PRPF3 PRPF40A RBM39 RBMX2 SRPK1 THAP1 TTC14 U2AF1	12 interactors: APBB1 DDX42 NKAP PIN1 PINX1 PRPF40A RBM17 TRA2A WBP4 YWHAB YWHAG ZGPAT
Entrez ID		79576	1665
HPRD ID		06666	04553
Ensembl ID		ENSG00000101882	ENSG00000109606
Uniprot IDs		Q8N5F7	O43143
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Type I Interferon Production Defense Response To Virus Ribonucleoprotein Complex Assembly Metabolic Process	RNA Splicing MRNA Processing Gene Expression Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway MRNA Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Cell Cycle RNA Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Cytokinesis Negative Regulation Of Transferase Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Thymidylate Synthase Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Mitochondrion Organization Regulation Of Protein Phosphorylation Nitrogen Compound Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation Regulation Of Phosphorylation Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process Cellular Response To Insulin Stimulus Negative Regulation Of Protein Kinase Activity Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Regulation Of Protein Kinase Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Intracellular Transport Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process
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