PIGR and RAB3B

Number of citations of the paper that reports this interaction (PubMedID 11832247)
0

Data Source:
HPRD (in vitro, in vivo)

		PIGR	RAB3B
Description		polymeric immunoglobulin receptor	RAB3B, member RAS oncogene family
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Azurophil Granule Membrane Receptor Complex Extracellular Exosome Secretory IgA Immunoglobulin Complex Bounding Membrane Of Organelle	Cytoplasm Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Synaptic Vesicle Membrane Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Dopaminergic Synapse
	Molecular Function	Polymeric Immunoglobulin Binding Polymeric Immunoglobulin Receptor Activity Transmembrane Signaling Receptor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Myosin V Binding
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Receptor Clustering	Exocytosis Protein Transport Regulation Of Exocytosis Antigen Processing And Presentation Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Vesicle Size Regulation Of Synaptic Vesicle Cycle
Pathways		Neutrophil degranulation	RAB geranylgeranylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Precuneus cortex volume ( 31530798)	Mean platelet volume ( 32888494)
Interacting Genes		4 interacting genes: AP1M1 CCL5 CD79A RAB3B	15 interacting genes: ACVR1 CALM1 CALM2 CALM3 CHM GDI1 PIGR RIMS2 RPH3A RPH3AL SGSM2 SMAD1 SMAD4 TGFBR1 VRTN
Entrez ID		5284	5865
HPRD ID		01436	01540
Ensembl ID		ENSG00000162896	ENSG00000169213
Uniprot IDs		P01833	P20337
PDB IDs		1XED 2OCW 3CHN 3CM9 5D4K 6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA 7K0C 7YSG 8SKU 8SKV	3DZ8 8A4B 8A4C
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Antagonist Activity Chemokine (C-C Motif) Ligand 5 Signaling Pathway CCR4 Chemokine Receptor Binding IgM B Cell Receptor Complex Immune System Process B Cell Receptor Complex Myosin V Binding Regulation Of Dopamine Uptake Involved In Synaptic Transmission GTP-dependent Protein Binding Secretion By Cell Positive Regulation Of Neurotransmitter Uptake Regulation Of Vesicle Size Vesicle-mediated Transport Dopaminergic Synapse Secretion Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Neurotransmitter Uptake Exocytosis Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Receptor Signaling Protein Tyrosine Kinase Activator Activity Regulation Of Cell-cell Adhesion Mediated By Integrin Eosinophil Migration Positive Regulation Of Natural Killer Cell Chemotaxis Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Macrophage Apoptotic Process Macrophage Chemotaxis Eosinophil Chemotaxis Positive Regulation Of Neuroinflammatory Response Dendritic Cell Migration Phospholipase Activator Activity Dendritic Cell Chemotaxis Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Myeloid Cell Apoptotic Process Host-mediated Suppression Of Viral Transcription Positive Regulation Of Homotypic Cell-cell Adhesion Macrophage Migration Monocyte Chemotaxis Negative Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Lymphocyte Chemotaxis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway CCR1 Chemokine Receptor Binding Positive Regulation Of T Cell Apoptotic Process Host-mediated Suppression Of Viral Proces	Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Adenylate Cyclase Activator Activity Myelin Sheath Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Small GTPase Binding Vesicle-mediated Transport Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling I-SMAD Binding Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Negative Regulation Of Transporter Activity Calcium Channel Complex Transforming Growth Factor Beta Receptor Signaling Pathway Protein-containing Complex Calcineurin-mediated Signaling Activin Receptor Signaling Pathway Detection Of Chemical Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intracellular Signaling Cassette Regulation Of Regulated Secretory Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Synaptic Vesicle Membrane Response To Calcium Ion Transmembrane Transporter Binding Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Spindle Microtubule Transforming Growth Factor Beta Receptor Activity, Type I Presynaptic Endocytosis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Substantia Nigra Development Calcium Channel Regulator Activity SMAD Binding Sperm Midpiece Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Spontaneous Neurotransmitter Secretion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?