PIGR and RAB3B

Number of citations of the paper that reports this interaction (PMID 11832247)
21

Data Source:
HPRD (in vitro, in vivo)

		PIGR	RAB3B
Gene Name		polymeric immunoglobulin receptor	RAB3B, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome	Cytoplasm Endosome Cytosol Plasma Membrane Synaptic Vesicle Secretory Granule Membrane Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Polymeric Immunoglobulin Receptor Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Retina Homeostasis Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Receptor Clustering	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Peptidyl-cysteine Methylation Antigen Processing And Presentation Rab Protein Signal Transduction Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Localization To Plasma Membrane Regulation Of Vesicle Size
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		4 interactors: AP1M1 CCL5 CD79A RAB3B	13 interactors: ACVR1 CALM1 CALM2 CALM3 CHM GDI1 PIGR RIMS2 RPH3A RPH3AL SMAD1 SMAD4 TGFBR1
Entrez ID		5284	5865
HPRD ID		01436	01540
Ensembl ID		ENSG00000162896	ENSG00000169213
Uniprot IDs		P01833	P20337
PDB IDs		1XED 2OCW 3CHN 3CM9	3DZ8
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Vesicle Size Positive Regulation Of Ion Transport Peptidyl-cysteine Methylation Negative Regulation Of Macrophage Apoptotic Process Regulation Of Immune System Process Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Chemokine-mediated Signaling Pathway Antigen Processing And Presentation Vesicle-mediated Transport Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Activation Of Janus Kinase Activity Exocytosis Positive Regulation Of Macrophage Chemotaxis Pigment Granule Maturation Endosome To Melanosome Transport Eosinophil Chemotaxis Eosinophil Migration Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of T Cell Chemotaxis Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Synaptic Transmission, Dopaminergic Cellular Pigment Accumulation Negative Regulation By Host Of Viral Transcription Positive Regulation Of Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Establishment Of Localization In Cell Regulation Of Macrophage Chemotaxis Regulation Of Monocyte Chemotaxis Positive Regulation Of Translational Initiation Dendritic Cell Chemotaxis Leukocyte Activation Activation Of Phospholipase D Activity Regulation Of Neurotransmitter Uptake Positive Regulation Of T Cell Apoptotic Process Monocyte Chemotaxis Regulation Of Macrophage Apoptotic Process Secretion By Cell Positive Regulation Of Cell Adhesion Mediated By Integrin Macrophage Chemotaxis Extracellular Negative Regulation Of Signal Transduction Positive Regulation Of T Cell Migration Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process Regulation Of T Cell Migration Negative Regulation Of Viral Transcription Melanosome Organization	Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Localization Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Regulation Of Intracellular Transport Positive Regulation Of Phosphoprotein Phosphatase Activity Intracellular Signal Transduction Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Midbrain Development Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Glycogen Catabolic Process Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Response To Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Exocytosis Positive Regulation Of Phosphatase Activity Response To Corticosterone Positive Regulation Of Metabolic Process Positive Regulation Of Cation Channel Activity Response To Amphetamine Second-messenger-mediated Signaling Positive Regulation Of Adenylate Cyclase Activity Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?		adenoids belonging defense degranulation destructive dimers eosinophils extravasation glandular helper iga ige immunopathology leukocytes migrate mucosa penetrating perhaps piga polymers priming reaches secretions secretory th2 tonsils transported unsuccessful	1h basilar camk2a camk2b capn1 capn2 cisplatin cochlea deacetylases ganglion hair hdacs immunocytochemistry label neurofilament neurotransmitter newborn organotypic ototoxicity panther phalloidin rhodamine sgns snap25 spiral tnfrsf1a trichostatin tsa vglut1
Tagcloud (Difference) ?		adenoids belonging defense degranulation destructive dimers eosinophils extravasation glandular helper iga ige immunopathology leukocytes migrate mucosa penetrating perhaps piga polymers priming reaches secretions secretory th2 tonsils transported unsuccessful	1h basilar camk2a camk2b capn1 capn2 cisplatin cochlea deacetylases ganglion hair hdacs immunocytochemistry label neurofilament neurotransmitter newborn organotypic ototoxicity panther phalloidin rhodamine sgns snap25 spiral tnfrsf1a trichostatin tsa vglut1
Tagcloud (Intersection) ?