PIGR and CCL5

Number of citations of the paper that reports this interaction (PubMedID 11509627)
0

Data Source:
HPRD (in vivo)

		PIGR	CCL5
Description		polymeric immunoglobulin receptor	C-C motif chemokine ligand 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Azurophil Granule Membrane Receptor Complex Extracellular Exosome Secretory IgA Immunoglobulin Complex Bounding Membrane Of Organelle	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Polymeric Immunoglobulin Binding Polymeric Immunoglobulin Receptor Activity Transmembrane Signaling Receptor Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity CCR1 Chemokine Receptor Binding CCR4 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity Chemokine Receptor Antagonist Activity CCR Chemokine Receptor Binding
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Receptor Clustering	Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Leukocyte Cell-cell Adhesion G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of TOR Signaling Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Response To Cytokine Positive Regulation Of Homotypic Cell-cell Adhesion Response To Tumor Necrosis Factor Chemokine (C-C Motif) Ligand 5 Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Host-mediated Suppression Of Viral Transcription Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Insulin Secretion Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Monocyte Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs			Heparin Disaccharide I-S Heparin Disaccharide Iii-S
Diseases
GWAS		Blood protein levels ( 30072576) Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Precuneus cortex volume ( 31530798)	Blood protein levels ( 30072576)
Interacting Genes		4 interacting genes: AP1M1 CCL5 CD79A RAB3B	55 interacting genes: ACKR1 ACKR2 ACKR4 APC BAG4 BCAR3 CCL11 CCL13 CCL16 CCL17 CCL2 CCL20 CCL21 CCL24 CCL25 CCL26 CCL27 CCL28 CCR1 CCR3 CCR4 CCR5 CHEK2 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 DPP4 EDC4 FZR1 GRB2 IGFBP7 KRAS PALB2 PF4 PHB1 PIGR PPBP PTPN1 RANGAP1 RELA SDC1 SDC4 SLC2A5 TGFB1 TRIP6 VCAN WT1 XCL1 XCL2
Entrez ID		5284	6352
HPRD ID		01436	01751
Ensembl ID		ENSG00000162896	ENSG00000271503
Uniprot IDs		P01833	A0A494C1Q1 D0EI67 P13501
PDB IDs		1XED 2OCW 3CHN 3CM9 5D4K 6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA 7K0C 7YSG 8SKU 8SKV	1B3A 1EQT 1HRJ 1RTN 1RTO 1U4L 1U4M 1U4P 1U4R 2L9H 2VXW 5CMD 5COY 5DNF 5L2U 5UIW 6AEZ 6C6D 6FGP 6LOG 6STK 7F1R 7O7F
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Antagonist Activity Chemokine (C-C Motif) Ligand 5 Signaling Pathway CCR4 Chemokine Receptor Binding IgM B Cell Receptor Complex Immune System Process B Cell Receptor Complex Myosin V Binding Regulation Of Dopamine Uptake Involved In Synaptic Transmission GTP-dependent Protein Binding Secretion By Cell Positive Regulation Of Neurotransmitter Uptake Regulation Of Vesicle Size Vesicle-mediated Transport Dopaminergic Synapse Secretion Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Neurotransmitter Uptake Exocytosis Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Receptor Signaling Protein Tyrosine Kinase Activator Activity Regulation Of Cell-cell Adhesion Mediated By Integrin Eosinophil Migration Positive Regulation Of Natural Killer Cell Chemotaxis Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Macrophage Apoptotic Process Macrophage Chemotaxis Eosinophil Chemotaxis Positive Regulation Of Neuroinflammatory Response Dendritic Cell Migration Phospholipase Activator Activity Dendritic Cell Chemotaxis Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Myeloid Cell Apoptotic Process Host-mediated Suppression Of Viral Transcription Positive Regulation Of Homotypic Cell-cell Adhesion Macrophage Migration Monocyte Chemotaxis Negative Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Lymphocyte Chemotaxis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway CCR1 Chemokine Receptor Binding Positive Regulation Of T Cell Apoptotic Process Host-mediated Suppression Of Viral Proces	Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Migration Cytokine Activity Leukocyte Chemotaxis Cell Motility Inflammatory Response Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Cytokine-mediated Signaling Pathway Immune Response Killing Of Cells Of Another Organism Defense Response Cell Killing Defense Response To Symbiont Defense Response To Other Organism Immune System Process Response To Stress CXCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Signal Transduction Response To Other Organism CCR Chemokine Receptor Binding Response To External Biotic Stimulus Extracellular Space Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Migration Eosinophil Chemotaxis Mononuclear Cell Migration Extracellular Region Positive Regulation Of Locomotion Eosinophil Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Leukocyte Migration Neutrophil Chemotaxis Chemokine Receptor Binding C-C Chemokine Binding Neutrophil Migration Positive Regulation Of Leukocyte Migration
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