LAMP1 and VSTM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LAMP1	VSTM1
Description		lysosomal associated membrane protein 1	V-set and transmembrane domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Cytosol Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Late Endosome Membrane Vesicle Azurophil Granule Membrane Sarcolemma Melanosome Cytolytic Granule Autolysosome Phagocytic Vesicle Perinuclear Region Of Cytoplasm Phagolysosome Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane Cytolytic Granule Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Ion Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding	Cytokine Activity Protein Binding
	Biological Process	Lysosomal Lumen Acidification Lysosomal Lumen PH Elevation Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Protein Stabilization Establishment Of Protein Localization To Organelle Golgi To Lysosome Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Regulation Of Organelle Transport Along Microtubule Proton Transmembrane Transport	Immune System Process Immune Response-regulating Signaling Pathway
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Small cell lung carcinoma ( 28604730)
Interacting Genes		4 interacting genes: AP1M1 AP2M1 SLC48A1 VSTM1	29 interacting genes: ADGRG3 APH1B AQP6 ARL13B CD53 CLDN7 CLDN9 CLEC10A COQ9 ERGIC3 FAM209A FATE1 FBXO2 FCGR1A FNDC9 GJB5 GOLM1 GPX8 HCST KCNJ6 LAMP1 LMNA LRRC4C MANSC1 MRM1 PLPP2 SLC60A2 STMN4 TMEM248
Entrez ID		3916	284415
HPRD ID		01076	15615
Ensembl ID		ENSG00000185896	ENSG00000189068
Uniprot IDs		B3KRY3 P11279	D2DJS5 D2DJS6 Q6UX27
PDB IDs		8ATH 8FY5 8FYF 9C59 9C5A 9C5B
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex Clathrin Adaptor Activity Lysosomal Membrane Heme Export From Vacuole To Cytoplasm Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Cytoplasmic Vesicle Plasma Membrane Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Phosphatidylinositol 3-kinase Activator Activity Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Proliferation Endolysosome Heme Transmembrane Transport Heme Transmembrane Transporter Activity Localization Of Cell Heme Export Heme Transport Phagolysosome Membrane Vacuolar Transmembrane Transport Vesicle-mediated Transport Intracellular Transport Positive Regulation Of Fatty Acid Beta-oxidation Cellular Response To Endothelin Endosome To Melanosome Transport Vesicle Organization AP-2 Adaptor Complex Response To Endothelin Regulation Of Type B Pancreatic Cell Proliferation AP-1 Adaptor Complex Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Fatty Acid Oxidation Regulation Of Vesicle Size Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Melanosome Assembly Iron Ion Transmembrane Transport Endolysosome Membrane Regulation Of B Cell Apoptotic Process Cellular Localization Endocytosis Establishment Of Localization In Cell Clathrin-coated Endocytic Vesicle	Membrane
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