LAMP1 and IRS2

Data Source: HiPPIP (Novel)

		LAMP1	IRS2
Name		lysosomal associated membrane protein 1	insulin receptor substrate 2
Structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Cytosol Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Late Endosome Membrane Vesicle Azurophil Granule Membrane Sarcolemma Melanosome Cytolytic Granule Autolysosome Phagocytic Vesicle Perinuclear Region Of Cytoplasm Phagolysosome Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane Cytolytic Granule Membrane	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Ion Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Lysosomal Lumen Acidification Lysosomal Lumen PH Elevation Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Protein Stabilization Establishment Of Protein Localization To Organelle Golgi To Lysosome Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Regulation Of Organelle Transport Along Microtubule Proton Transmembrane Transport	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Cell Migration Regulation Of Lipid Metabolic Process Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lipid Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Endothelin
Pathways		Neutrophil degranulation	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Growth hormone receptor signaling
GWAS		Bipolar disorder ( 31043756 )	Alanine aminotransferase levels ( 34315874 ) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353 ) Aspartate aminotransferase levels ( 34315874 ) Heel bone mineral density ( 28869591 30598549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) Insulin-related traits (multivariate analysis) ( 32002517 ) Mean corpuscular hemoglobin ( 27863252 29403010 32888494 ) Mean corpuscular volume ( 27863252 32888494 29403010 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Nose size ( 27182965 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Platelet count ( 29403010 ) Prostate cancer ( 29117387 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 27863252 ) Type 2 diabetes ( 30297969 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) White matter lesion progression ( 26451028 ) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028 )
Novel Interactors		1 novel interactors: IRS2	10 novel interactors: CDKL1 CUL4A EDEM1 LAMP1 MPO NRAS PROZ PTPRR RAP2A SLC35B1
Interacting Genes		4 interacting genes: AP1M1 AP2M1 SLC48A1 VSTM1	40 interacting genes: AP2M1 ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL MTDH NEDD4 NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SOCS1 SOCS3 SOCS6 SOCS7 SRPK2 TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID		3916	8660
HPRD ID		01076	02878
Ensembl ID		ENSG00000185896	ENSG00000185950
Uniprot IDs		B3KRY3 P11279	Q9P084 Q9Y4H2
PDB IDs		8ATH 8FY5 8FYF 9C59 9C5A 9C5B	3FQW 3FQX
GO Terms Enriched among Interactors		Clathrin Adaptor Complex Clathrin Adaptor Activity Lysosomal Membrane Heme Export From Vacuole To Cytoplasm Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Cytoplasmic Vesicle Plasma Membrane Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Phosphatidylinositol 3-kinase Activator Activity Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Proliferation Endolysosome Heme Transmembrane Transport Heme Transmembrane Transporter Activity Localization Of Cell Heme Export Heme Transport Phagolysosome Membrane Vacuolar Transmembrane Transport Vesicle-mediated Transport Intracellular Transport Positive Regulation Of Fatty Acid Beta-oxidation Cellular Response To Endothelin Endosome To Melanosome Transport Vesicle Organization AP-2 Adaptor Complex Response To Endothelin Regulation Of Type B Pancreatic Cell Proliferation AP-1 Adaptor Complex Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Fatty Acid Oxidation Regulation Of Vesicle Size Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Melanosome Assembly Iron Ion Transmembrane Transport Endolysosome Membrane Regulation Of B Cell Apoptotic Process Cellular Localization Endocytosis Establishment Of Localization In Cell Clathrin-coated Endocytic Vesicle	Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Phosphotyrosine Residue Binding Protein Modification Process Insulin Receptor Substrate Binding Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Binding Protein Phosphorylation Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Cell Adhesion Phosphorylation Regulation Of Immune System Process Regulation Of Cell Communication Regulation Of Signaling Cytokine-mediated Signaling Pathway Regulation Of Cellular Localization Negative Regulation Of Immune System Process Immune System Process Phosphate-containing Compound Metabolic Process Protein Metabolic Process Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Neurotrophin TRKA Receptor Binding Phosphoserine Residue Binding Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Response To Stress Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Population Proliferation Cell Activation Protein Tyrosine Kinase Activity Regulation Of Intracellular Transport Phosphatidylinositol 3-kinase Complex Leukocyte Activation Lymphocyte Activation Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Regulation Of Leukocyte Cell-cell Adhesion Intracellular Signaling Cassette Regulation Of T Cell Activation