LAMP1

Name	lysosomal associated membrane protein 1
Structure
Novel Interactors	1 novel interactors: IRS2
Interactors	4 interactors: AP1M1 AP2M1 SLC48A1 VSTM1
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Cytosol Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Late Endosome Membrane Vesicle Azurophil Granule Membrane Sarcolemma Melanosome Cytolytic Granule Autolysosome Phagocytic Vesicle Perinuclear Region Of Cytoplasm Phagolysosome Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane Cytolytic Granule Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Ion Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding
	Biological Process	Lysosomal Lumen Acidification Lysosomal Lumen PH Elevation Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Protein Stabilization Establishment Of Protein Localization To Organelle Golgi To Lysosome Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Regulation Of Organelle Transport Along Microtubule Proton Transmembrane Transport
Pathways	Neutrophil degranulation
GWAS	Bipolar disorder ( 31043756 )
Entrez ID	3916
HPRD ID	01076
Ensembl ID	ENSG00000185896
Uniprot IDs	B3KRY3 P11279
PDB IDs	8ATH 8FY5 8FYF 9C59 9C5A 9C5B
GO Terms Enriched among Interactors ?	Clathrin Adaptor Complex Clathrin Adaptor Activity Lysosomal Membrane Heme Export From Vacuole To Cytoplasm Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Cytoplasmic Vesicle Plasma Membrane Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Phosphatidylinositol 3-kinase Activator Activity Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Proliferation Endolysosome Heme Transmembrane Transport Heme Transmembrane Transporter Activity Localization Of Cell Heme Export Heme Transport Phagolysosome Membrane Vacuolar Transmembrane Transport Vesicle-mediated Transport Intracellular Transport Positive Regulation Of Fatty Acid Beta-oxidation Cellular Response To Endothelin Endosome To Melanosome Transport Vesicle Organization AP-2 Adaptor Complex Response To Endothelin Regulation Of Type B Pancreatic Cell Proliferation AP-1 Adaptor Complex Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Fatty Acid Oxidation Regulation Of Vesicle Size Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Melanosome Assembly Iron Ion Transmembrane Transport Endolysosome Membrane Regulation Of B Cell Apoptotic Process Cellular Localization Endocytosis Establishment Of Localization In Cell Clathrin-coated Endocytic Vesicle