DUX4L9 and FHL3

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (two hybrid)

		DUX4L9	FHL3
Description		double homeobox 4 like 9 (pseudogene)	four and a half LIM domains 3
Image		No pdb structure
GO Annotations	Cellular Component		Stress Fiber Nucleus Cytoplasm Focal Adhesion Z Disc
	Molecular Function		Transcription Coregulator Activity Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process		Muscle Organ Development Actin Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		10 interacting genes: ACTA1 ACTN3 FHL3 MSS51 MYH2 NDUFB10 RBM24 RPL4 SF1 VDAC2	181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CIMAP1B CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM222B FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GARIN6 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 HYCC1 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYCBP2 MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PIERCE1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SAXO4 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SPMAP2 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 TLE5 TMEM108 TMEM14B TMSB4X TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587
Entrez ID		100288711	2275
HPRD ID			09101
Ensembl ID		ENSG00000224807	ENSG00000183386
Uniprot IDs			Q13643 Q96C98
PDB IDs			1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?		Sarcomere Actin Filament Muscle System Process Stress Fiber Regulation Of Myotube Differentiation Actin Binding Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Muscle Cell Differentiation Muscle Cell Development Actin Filament-based Process Positive Regulation Of Bone Mineralization Involved In Bone Maturation Focal Adhesion Positive Regulation Of Skeletal Muscle Fiber Differentiation Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Negative Regulation Of Relaxation Of Muscle Regulation Of Muscle Cell Differentiation Response To Denervation Involved In Regulation Of Muscle Adaptation Positive Regulation Of Skeletal Muscle Tissue Growth Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Z Disc Porin Activity Voltage-gated Monoatomic Anion Channel Activity U2AF Complex MRNA 3'-splice Site Recognition Positive Regulation Of 3'-UTR-mediated MRNA Stabilization MRNA CDS Binding Regulation Of Skeletal Muscle Fiber Differentiation Striated Muscle Thin Filament Muscle Atrophy Response To Muscle Inactivity Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Ribosome Ceramide Binding Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Cytoplasmic Translation Positive Regulation Of Skeletal Muscle Cell Differentiation Muscle Contraction Regulation Of Skeletal Muscle Fiber Development Actin Filament Binding	Protein Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Transcription Coregulator Binding DNA-binding Transcription Factor Activity Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Phosphatase Binding Positive Regulation Of Macromolecule Metabolic Process Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Identical Protein Binding SMAD Protein Complex Sequence-specific Double-stranded DNA Binding Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Myelination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axon Ensheathment
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