EIF2B5 and CSNK1A1

Number of citations of the paper that reports this interaction (PubMedID 11500362)
34

Data Source:
HPRD (in vitro, in vivo)

		EIF2B5	CSNK1A1
Description		eukaryotic translation initiation factor 2B subunit epsilon	casein kinase 1 alpha 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cytoskeleton Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Cell Projection Keratin Filament
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Ovarian Follicle Development Cytoplasmic Translational Initiation Translation Translational Initiation Response To Heat Response To Glucose Astrocyte Development Oligodendrocyte Development Hippocampus Development Response To Endoplasmic Reticulum Stress Myelination Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Translation Positive Regulation Of Translational Initiation Astrocyte Differentiation T Cell Receptor Signaling Pathway	Autophagosome Assembly Protein Phosphorylation Golgi Organization Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Viral Protein Processing Regulation Of Wnt Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Nutrient Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rho Protein Signal Transduction TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Recycling of eIF2:GDP	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Maturation of nucleoprotein
Drugs			Fostamatinib
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 27863252 32888494) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)
Interacting Genes		13 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B RNF10 STX11	51 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC ATM AXIN1 BID CDC25A CEBPA CHRM3 CRBN CREM CTNNB1 CUL4B EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MDM4 NFATC3 NLRP3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 USP15 UVRAG YWHAQ YWHAZ
Entrez ID		8893	1452
HPRD ID		04898	02739
Ensembl ID		ENSG00000145191	ENSG00000113712
Uniprot IDs		A0A3B3ISX3 Q13144	B4DER9 P48729 Q6PJ06
PDB IDs		3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ	5FQD 6GZD 7WTT 8G66
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-catenin Destruction Complex Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Tau-protein Kinase Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Wnt Signaling Pathway Viral Protein Processing Regulation Of Glycogen Biosynthetic Process ATP Binding Protein Kinase CK2 Complex Negative Regulation Of Signal Transduction Cytoplasmic Translational Initiation Macromolecule Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Glycogen Metabolic Process Regulation Of Glycogen (starch) Synthase Activity Viral Process Tau Protein Binding Regulation Of Autophagy Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Autophagy Regulation Of Amyloid Precursor Protein Catabolic Process Transferase Activity Negative Regulation Of Intracellular Signal Transduction Cellular Response To Interleukin-3 Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Glycogen Biosynthetic Process	Protein-containing Complex Signal Transduction Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Development Ubiquitin Protein Ligase Binding Protein Domain Specific Binding Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Development Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Cellular Component Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of T Cell Activation Regulation Of Metabolic Process Regulation Of Stem Cell Proliferation T Cell Differentiation In Thymus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Lung Development Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Cytoplasm Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Apoptotic Process
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