EIF2B5 and EIF2B2

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (pull down, biochemical)
HPRD (in vitro)

		EIF2B5	EIF2B2
Gene Name		eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity
	Biological Process	Ovarian Follicle Development Translation Translational Initiation Response To Heat Response To Glucose Gene Expression Astrocyte Development Oligodendrocyte Development Negative Regulation Of Translational Initiation In Response To Stress Response To Endoplasmic Reticulum Stress Cellular Response To Drug Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Astrocyte Differentiation	Ovarian Follicle Development Translation Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Protein-Protein Interactions		11 interactors: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 EIF2B1 EIF2B2 EIF2B4 EIF2S2 GSK3A GSK3B	10 interactors: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1
Entrez ID		8893	8892
HPRD ID		04898	05923
Ensembl ID		ENSG00000145191	ENSG00000119718
Uniprot IDs		Q13144	P49770 Q53XC2
PDB IDs		3JUI
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Response To Heat Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Oligodendrocyte Development Nervous System Development Hypermethylation Of CpG Island Negative Regulation Of Protein Metabolic Process Response To Temperature Stimulus Cellular Response To Interleukin-3 Neurogenesis Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Hydrolase Activity Translational Initiation Negative Regulation Of Glycogen (starch) Synthase Activity Cell Development Protein Metabolic Process Regulation Of Translational Initiation Regulation Of Translation Negative Regulation Of Translation In Response To Stress Oligodendrocyte Differentiation System Development Regulation Of Wnt Signaling Pathway Rhythmic Process Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cellular Metabolic Process Protein Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Glial Cell Development Multicellular Organismal Development Regulation Of Type B Pancreatic Cell Development Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Mitotic Nuclear Division Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Translation In Response To Stress Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Anatomical Structure Development Regulation Of Mitotic Cell Cycle Response To Glucose Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Negative Regulation Of Translational Initiation	Regulation Of Translation In Response To Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Translation In Response To Stress Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Oligodendrocyte Development Regulation Of Cellular Protein Metabolic Process Translational Initiation Regulation Of Protein Metabolic Process Oligodendrocyte Differentiation Negative Regulation Of Translation Glial Cell Development Neurogenesis Response To Heat Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Response To Glucose Cell Development Positive Regulation Of Hydrolase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Cellular Metabolic Process Glial Cell Differentiation Response To Carbohydrate Response To Temperature Stimulus Nervous System Development Protein Metabolic Process Regulation Of Catalytic Activity Translation Gliogenesis Cellular Response To Stress Positive Regulation Of Catalytic Activity Central Nervous System Development Ovarian Follicle Development Axon Guidance Positive Regulation Of Translation Reproduction Regulation Of Gene Expression Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Response To Abiotic Stimulus Cell Differentiation Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stress
Tagcloud ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm	actb aging analysed comprehensive cows deltact differed dominant durations follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold ube2d2
Tagcloud (Difference) ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm	actb aging analysed comprehensive cows deltact differed dominant durations follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold ube2d2
Tagcloud (Intersection) ?