EIF2B5 and EIF2S2

Number of citations of the paper that reports this interaction (PubMedID 31839598)
57

Data Source:
BioGRID (cross-linking study, cross-linking study)
HPRD (in vitro)

		EIF2B5	EIF2S2
Description		eukaryotic translation initiation factor 2B subunit epsilon	eukaryotic translation initiation factor 2 subunit beta
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex Synapse
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Zinc Ion Binding Translation Initiation Factor Binding Metal Ion Binding
	Biological Process	Ovarian Follicle Development Cytoplasmic Translational Initiation Translation Translational Initiation Response To Heat Response To Glucose Astrocyte Development Oligodendrocyte Development Hippocampus Development Response To Endoplasmic Reticulum Stress Myelination Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Translation Positive Regulation Of Translational Initiation Astrocyte Differentiation T Cell Receptor Signaling Pathway	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Male Germ Cell Proliferation Cytoplasmic Translational Initiation Translation Translational Initiation Male Gonad Development
Pathways		Recycling of eIF2:GDP	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 27863252 32888494) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)
Interacting Genes		13 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B RNF10 STX11	25 interacting genes: APLP1 APP CCDC90B CEBPA CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 NCK1 OGT PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16
Entrez ID		8893	8894
HPRD ID		04898	04882
Ensembl ID		ENSG00000145191	ENSG00000125977
Uniprot IDs		A0A3B3ISX3 Q13144	P20042 Q6IBR8
PDB IDs		3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ	6K71 6K72 6YBV 6ZMW 6ZP4 7A09 7D43 7QP6 8OZ0 8PJ1 8PPL
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-catenin Destruction Complex Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Tau-protein Kinase Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Wnt Signaling Pathway Viral Protein Processing Regulation Of Glycogen Biosynthetic Process ATP Binding Protein Kinase CK2 Complex Negative Regulation Of Signal Transduction Cytoplasmic Translational Initiation Macromolecule Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Glycogen Metabolic Process Regulation Of Glycogen (starch) Synthase Activity Viral Process Tau Protein Binding Regulation Of Autophagy Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Autophagy Regulation Of Amyloid Precursor Protein Catabolic Process Transferase Activity Negative Regulation Of Intracellular Signal Transduction Cellular Response To Interleukin-3 Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Glycogen Biosynthetic Process	Translation Initiation Factor Activity Regulation Of Translation Eukaryotic Translation Initiation Factor 2B Complex Translational Initiation Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Glial Cell Development Translation Oligodendrocyte Development Central Nervous System Development Cytoplasmic Translational Initiation Response To Heat T Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Response To Glucose Signal Transduction Transcription Regulator Complex Cytosol Response To Monosaccharide Cell Surface Receptor Signaling Pathway Response To Hormone Response To Temperature Stimulus Antigen Receptor-mediated Signaling Pathway Response To Carbohydrate Protein-containing Complex Organization Cell Development Regulation Of Apoptotic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Eukaryotic Initiation Factor EIF2 Binding Macromolecule Biosynthetic Process Response To Peptide Hormone Molecular Function Activator Activity Cell Death Cellular Response To Norepinephrine Stimulus Macromolecule Metabolic Process Response To Norepinephrine Protein-containing Complex Assembly Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Programmed Cell Death Regulation Of Proteolysis Protein Domain Specific Binding PML Body Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process B Cell Lineage Commitment
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