EIF2B5 and CSNK2A2

Number of citations of the paper that reports this interaction (PubMedID 11500362)
34

Data Source:
HPRD (in vitro, in vivo)

		EIF2B5	CSNK2A2
Description		eukaryotic translation initiation factor 2B subunit epsilon	casein kinase 2 alpha 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Cytosol Protein Kinase CK2 Complex PcG Protein Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Ovarian Follicle Development Cytoplasmic Translational Initiation Translation Translational Initiation Response To Heat Response To Glucose Astrocyte Development Oligodendrocyte Development Hippocampus Development Response To Endoplasmic Reticulum Stress Myelination Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Translation Positive Regulation Of Translational Initiation Astrocyte Differentiation T Cell Receptor Signaling Pathway	Double-strand Break Repair Apoptotic Process DNA Damage Response Spermatogenesis Wnt Signaling Pathway Cerebral Cortex Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Liver Regeneration Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Recycling of eIF2:GDP	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs			[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 27863252 32888494) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)
Interacting Genes		13 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B RNF10 STX11	104 interacting genes: ABCA1 ACACA ADH1A AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CEBPA CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERCC6 ERH FGF1 FGF2 FKBP3 FOS GRIN2A GRIN2B GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PICK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3
Entrez ID		8893	1459
HPRD ID		04898	00279
Ensembl ID		ENSG00000145191	ENSG00000070770
Uniprot IDs		A0A3B3ISX3 Q13144	P19784
PDB IDs		3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ	3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6L20 6QY8 6QY9 6TE2 6TEW 6TGU 7A1B 7A1Z 7A22 7A2H 7AT9 7ATV 7XYH 8Q77 8Q9S 8QBU 8QCD 8QCG 8QF1
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-catenin Destruction Complex Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Tau-protein Kinase Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Wnt Signaling Pathway Viral Protein Processing Regulation Of Glycogen Biosynthetic Process ATP Binding Protein Kinase CK2 Complex Negative Regulation Of Signal Transduction Cytoplasmic Translational Initiation Macromolecule Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Glycogen Metabolic Process Regulation Of Glycogen (starch) Synthase Activity Viral Process Tau Protein Binding Regulation Of Autophagy Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Autophagy Regulation Of Amyloid Precursor Protein Catabolic Process Transferase Activity Negative Regulation Of Intracellular Signal Transduction Cellular Response To Interleukin-3 Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Glycogen Biosynthetic Process	Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Enzyme Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Alcohol Regulation Of Signal Transduction Regulation Of Metabolic Process Macromolecule Metabolic Process Protein-containing Complex Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Response To Stress Response To Alkaloid Regulation Of Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Signal Transduction Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of RNA Metabolic Process
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