ARK2N and MORC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ARK2N	MORC3
Description		arkadia (RNF111) N-terminal like PKA signaling regulator 2N	MORC family CW-type zinc finger 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Matrix PML Body
	Molecular Function	Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Activity	DNA Binding RNA Binding Protein Binding Zinc Ion Binding ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Release From Viral Latency Negative Regulation Of DNA-templated Transcription Negative Regulation Of Viral Life Cycle	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Chromatin Organization Protein Phosphorylation Post-embryonic Development Peptidyl-serine Phosphorylation Negative Regulation Of Interferon-beta Production Innate Immune Response Negative Regulation Of Fibroblast Proliferation Protein Stabilization Maintenance Of Protein Location In Nucleus Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Cellular Senescence
Pathways
Drugs
Diseases
GWAS			Diastolic blood pressure ( 30224653) Height ( 31562340)
Interacting Genes		15 interacting genes: DDIT4L ERG JAKMIP1 LRRK2 MCRS1 MORC3 RNF4 SRPK1 SRPK2 SUMO1 SUMO1P1 SUMO2 TAX1BP1 UBC UBE2I	25 interacting genes: ARK2N COPS5 DST DYNLL1 ERCC6 KALRN KIF3A KPNA2 KPNA4 MKLN1 PIAS1 PIAS3 PTK2 RANBP9 RETREG1 RNF123 RNF216 SNAPIN SPTBN4 SRI SUMO2 SUMO3 UBC UBE2I ZMYM5
Entrez ID		147339	23515
HPRD ID		12690	10316
Ensembl ID		ENSG00000152242	ENSG00000159256
Uniprot IDs		Q96B23	B4DHJ4 Q14149 Q4VBZ9
PDB IDs			4QQ4 5SVI 5SVX 5SVY 6O1E 6O5W
Enriched GO Terms of Interacting Partners?		Protein Modification Process PML Body Protein Tag Activity Protein Metabolic Process Presynaptic Cytosol Protein Sumoylation Nuclear Body Organization Transcription Factor Binding Protein Modification By Small Protein Conjugation Ubiquitin-like Protein Ligase Binding Postsynaptic Cytosol Post-translational Protein Modification Macromolecule Metabolic Process Small Protein Activating Enzyme Binding Protein Phosphorylation Phosphorylation RNA Binding PML Body Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Nucleus Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process SUMO Transferase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nuclear Body Positive Regulation Of Viral Genome Replication Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Magnesium Ion Binding Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Peptidyl-serine Phosphorylation SUMO Conjugating Enzyme Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Glutamatergic Synapse Negative Regulation Of Intracellular Transport Positive Regulation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Protein Localization To Phagocytic Vesicle Negative Regulation Of Late Endosome To Lysosome Transport Amphisome	Protein Sumoylation SUMO Transferase Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Post-translational Protein Modification PML Body Protein Modification Process Protein Tag Activity Axon Cytoplasm Protein Metabolic Process Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Nucleoplasm Macromolecule Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Transport Microtubule Anchoring At Centrosome Cellular Localization Axonal Transport Negative Regulation Of Heart Rate SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Microtubule Anchoring At Microtubule Organizing Center Transport Along Microtubule Cell Cortex Axo-dendritic Transport Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Cytosol Microtubule-based Transport Nuclear Import Signal Receptor Activity Retrograde Axonal Transport Negative Regulation Of Heart Contraction Cytoplasm Enzyme Binding Nuclear Localization Sequence Binding Negative Regulation Of Blood Circulation Regulation Of Protein Sumoylation NLS-bearing Protein Import Into Nucleus Microtubule Anchoring Regulation Of Protein Modification Process Establishment Of Vesicle Localization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Spectrin Binding Proteolysis Involved In Protein Catabolic Process Establishment Of Organelle Localization Vesicle Localization
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