ALDH1A2 and HTRA2

Number of citations of the paper that reports this interaction (PMID 17266347)
23

Data Source:
BioGRID (unspecified method)

		ALDH1A2	HTRA2
Gene Name		aldehyde dehydrogenase 1 family, member A2	HtrA serine peptidase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane CD40 Receptor Complex
	Molecular Function	Retinal Dehydrogenase Activity 3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD) Activity Retinal Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Unfolded Protein Binding
	Biological Process	Blood Vessel Development Kidney Development Liver Development Regulation Of Endothelial Cell Proliferation Heart Morphogenesis Vitamin A Metabolic Process Midgut Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Determination Of Bilateral Symmetry Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Neural Crest Cell Development Morphogenesis Of Embryonic Epithelium Neural Tube Development Pituitary Gland Development Neuron Differentiation Lung Development Hindbrain Development Pancreas Development Embryonic Camera-type Eye Development Response To Estradiol Response To Vitamin A Response To Cytokine Embryonic Forelimb Morphogenesis Ureter Maturation Retinol Metabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process 9-cis-retinoic Acid Biosynthetic Process Positive Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Cardiac Muscle Tissue Development Oxidation-reduction Process Face Development Cellular Response To Retinoic Acid	Proteolysis Ceramide Metabolic Process Mitochondrion Organization Adult Walking Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Positive Regulation Of Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Neuron Development Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Degradation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		Signaling by Retinoic Acid RA biosynthesis pathway
Drugs		NADH Vitamin A Tretinoin Nicotinamide-Adenine-Dinucleotide
Diseases
GWAS		Hypertension ( 19609347)
Protein-Protein Interactions		1 interactors: HTRA2	37 interactors: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 PAG1 PDXDC1 PDXDC2P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P USP7 VIM VPS4B XIAP
Entrez ID		8854	27429
HPRD ID		04733	05919
Ensembl ID		ENSG00000128918	ENSG00000115317
Uniprot IDs		O94788	O43464
PDB IDs			1LCY 2PZD
Enriched GO Terms of Interacting Partners?		Pentacyclic Triterpenoid Metabolic Process Response To Herbicide Protein Autoprocessing Regulation Of Mitochondrion Degradation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cellular Response To Interferon-beta Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Interferon-beta Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Adult Walking Behavior Regulation Of Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Retinoic Acid Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Ceramide Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Autophagy Response To Heat Adult Locomotory Behavior Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Isoprenoid Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Retinoic Acid Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Sphingolipid Metabolic Process Adult Behavior Cellular Response To Acid Chemical Response To Toxic Substance Intrinsic Apoptotic Signaling Pathway Response To Temperature Stimulus Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Death Regulation Of Cysteine-type Endopeptidase Activity Membrane Lipid Metabolic Process Locomotory Behavior Protein Processing Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Developmental Growth	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Proteolysis Cellular Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Proteolysis Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Protein Metabolic Process Protein Metabolic Process Regulation Of Protein Processing Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Toll-like Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Death Cellular Response To Stimulus MAPK Cascade Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Peptidase Activity Cellular Response To Stress Cellular Protein Modification Process Signal Transduction By Phosphorylation Response To Organic Substance Cellular Response To DNA Damage Stimulus Positive Regulation Of Innate Immune Response Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Neurotrophin Signaling Pathway
Tagcloud ?		box cooperative csf dcs dehydrogenase dendritic ectopic encoded fms generating gm granulocyte gut le540 mithramycin mostly peritoneal plasmacytoid potently ra raralpha rxr rxralpha sp1 synergistically tata unmethylated weakly	betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer
Tagcloud (Difference) ?		box cooperative csf dcs dehydrogenase dendritic ectopic encoded fms generating gm granulocyte gut le540 mithramycin mostly peritoneal plasmacytoid potently ra raralpha rxr rxralpha sp1 synergistically tata unmethylated weakly	betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer
Tagcloud (Intersection) ?