FBN3 and NUDT21

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		FBN3	NUDT21
Gene Name		fibrillin 3	nudix (nucleoside diphosphate linked moiety X)-type motif 21
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix	Nucleus Nucleoplasm Centrosome MRNA Cleavage Factor Complex Paraspeckles
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding	RNA Binding MRNA Binding Protein Binding Hydrolase Activity AU-rich Element Binding Protein Homodimerization Activity Histone Deacetylase Binding Poly(A) RNA Binding
	Biological Process		MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Processing RNA Splicing Gene Expression MRNA 3'-end Processing Protein Tetramerization
Pathways		Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ANXA7 BID C11orf58 CDKN1A DAZAP2 GADD45A GSK3B NUDT21 PIK3R3 RPN2 RPS6KA6 TK1 TSC22D1	51 interactors: A2M ATXN1 CARM1 CLP1 CPSF6 CPSF7 CTNND2 DBN1 DNMT3L DYNC1I1 EED EEF1G EXOSC6 F13A1 FBN3 FLAD1 FUNDC2 GOLGA2 HSF4 IKZF1 ITCH JMJD1C KIAA1377 KIFAP3 MASP1 MYL6 NEDD4 NGEF NIF3L1 POLR2C PSMF1 PTN PYCR1 RBM48 RCC1 RNF19A RPLP1 SEMA5B SF3B1 SHC1 SHFM1 SLC44A1 SNCAIP SNRNP70 SRPK1 TCERG1 TLE1 TRA2A TRIM27 WWOX ZBTB48
Entrez ID		84467	11051
HPRD ID		10538	05400
Ensembl ID		ENSG00000142449	ENSG00000167005
Uniprot IDs		Q75N90	O43809
PDB IDs			2CL3 2J8Q 3BAP 3BHO 3MDG 3MDI 3N9U 3P5T 3P6Y 3Q2S 3Q2T
Enriched GO Terms of Interacting Partners?		Signal Transduction In Response To DNA Damage Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Protein Kinase Activity Positive Regulation Of Apoptotic Process Negative Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Mitochondrion Organization Cellular Response To Ionizing Radiation Negative Regulation Of Transferase Activity Regulation Of Apoptotic Process Negative Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Response To Metal Ion Fetal Process Involved In Parturition Cellular Response To Stress Regulation Of Cell Death Apoptotic Signaling Pathway Cellular Response To DNA Damage Stimulus Cellular Response To Mechanical Stimulus Response To Organic Substance Response To Organic Cyclic Compound DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Hormone Regulation Of Mitochondrion Organization Negative Regulation Of Type B Pancreatic Cell Development Skeletal Muscle Cell Proliferation Superior Temporal Gyrus Development Apoptotic Process Protein Oligomerization Regulation Of Intracellular Transport Programmed Cell Death Protein Tetramerization Extrinsic Apoptotic Signaling Pathway Response To External Stimulus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Death Death Phosphorylation Intracellular Signal Transduction Response To Heat Signal Transduction By P53 Class Mediator Response To Inorganic Substance Re-entry Into Mitotic Cell Cycle	Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Process Cellular Metabolic Process Viral Process Protein K63-linked Ubiquitination RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Polyubiquitination Negative Regulation Of Complement Activation MRNA 3'-end Processing Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Immune System Process Developmental Process RNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Regulation Of Dendrite Development Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression By Genetic Imprinting Blood Coagulation Macromolecule Biosynthetic Process Hemostasis Protein Oligomerization MRNA Polyadenylation Anatomical Structure Development
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