CFLAR and ATF2

		CFLAR	ATF2
Description		CASP8 and FADD like apoptosis regulator	activating transcription factor 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Ripoptosome	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Site Of Double-strand Break RNA Polymerase II Transcription Regulator Complex H4 Histone Acetyltransferase Complex
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Cysteine-type Peptidase Activity Protein-containing Complex Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Protein Kinase Binding CAMP Response Element Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Sequence-specific DNA Binding Histone H2B Acetyltransferase Activity Metal Ion Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Response To Hypoxia Proteolysis Apoptotic Process Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Macrophage Differentiation Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Skeletal Muscle Tissue Regeneration Positive Regulation Of Neuron Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade In Utero Embryonic Development NK T Cell Differentiation Liver Development Hematopoietic Progenitor Cell Differentiation Outflow Tract Morphogenesis Brainstem Development Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Lipid Metabolic Process Apoptotic Process Response To Osmotic Stress DNA Damage Response Vacuole Organization JNK Cascade Heart Development Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Peptidyl-threonine Phosphorylation Abducens Nucleus Development Hypoglossal Nucleus Development Facial Nucleus Development BMP Signaling Pathway Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Oxidative Stress P38MAPK Cascade MRNA Transcription By RNA Polymerase II Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II White Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Neurofilament Cytoskeleton Organization Detection Of Cell Density Adipose Tissue Development Cellular Response To Anisomycin Motor Neuron Apoptotic Process Hepatocyte Apoptotic Process Cellular Response To Virus Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Development Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Cellular Response To Leucine Starvation
Pathways		TRAIL signaling	Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs			Pseudoephedrine
Diseases
GWAS		Appendicular lean mass ( 33097823) Rheumatoid arthritis ( 24390342 30423114) Triptolide cytotoxicity ( 26121980)	Intake of total sugars ( 31005972) Metabolite levels ( 23823483)
Interacting Genes		34 interacting genes: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CUL1 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 MEX3B NEURL3 NFKB1 PSEN2 RAF1 RBX1 RIPK1 RIPK2 RLIM RNF8 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 TRIM31 USP8	61 interacting genes: APP AR ATF3 ATF4 ATF7 BACH1 BANP BATF CCDC6 CCND1 CEBPA CEBPB CEBPG CREB5 CSNK2A1 CSNK2A2 DDIT3 DNMT3L EDF1 ETS1 EXOSC8 FAM13A-AS1 FOS GTF2F2 H2BC21 HMGA1 IRF2BP1 JDP2 JUN KIFC3 LHX8 MACROH2A1 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PIAS2 PML PRKCE RB1 RNF4 RPS6KA5 RUVBL2 SMAD3 SMAD4 SPOPL SRA1 SUMO1 THRB UBE2I USP14 UTF1 XPO1 YY1
Entrez ID		8837	1386
HPRD ID		04671	00443
Ensembl ID		ENSG00000003402	ENSG00000115966
Uniprot IDs		A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61	A4D7V5 P15336
PDB IDs		2N5R 3H11 3H13 6M6O 7DEE 7LXC 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN	1BHI 1T2K 4H36 6ZQS 6ZR5
Enriched GO Terms of Interacting Partners?		Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway Signal Transduction Protein Metabolic Process JNK Cascade Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Ripoptosome Intracellular Signaling Cassette Positive Regulation Of Neuron Apoptotic Process Proteolysis Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Execution Phase Of Apoptosis Response To Stress Cytosol Protein Modification Process Post-translational Protein Modification Response To External Biotic Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Staurosporine Death Effector Domain Binding Protein Polyubiquitination Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death Receptor Binding T Cell Activation Regulation Of Intracellular Signal Transduction Protein Maturation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cytokine Production	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Intracellular Signaling Cassette Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity DNA Binding Response To Stress Transcription Cis-regulatory Region Binding Integrated Stress Response Signaling Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity MAPK Cascade RNA Polymerase II-specific DNA-binding Transcription Factor Binding Macromolecule Metabolic Process DNA Damage Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cellular Senescence Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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