PGF and FLT1

Number of citations of the paper that reports this interaction (PMID 14684734)
12

Data Source:
HPRD (in vitro)

		PGF	FLT1
Gene Name		placental growth factor	fms-related tyrosine kinase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane	Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Receptor Complex
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding VEGF-A-activated Receptor Activity VEGF-B-activated Receptor Activity Placental Growth Factor-activated Receptor Activity Identical Protein Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Proliferation Cell Differentiation Organ Regeneration Cellular Response To Hormone Stimulus Response To Drug Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Division Regulation Of Morphogenesis Of A Branching Structure	Patterning Of Blood Vessels Sprouting Angiogenesis Monocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF	VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF Neurophilin interactions with VEGF and VEGFR
Drugs			Sorafenib Sunitinib Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib
Diseases
GWAS			Cognitive performance ( 19734545) Coronary heart disease ( 23364394)
Protein-Protein Interactions		4 interactors: FLT1 NRP1 NRP2 VEGFA	24 interactors: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1
Entrez ID		5228	2321
HPRD ID		03076	01297
Ensembl ID		ENSG00000119630	ENSG00000102755
Uniprot IDs		G3XA84 P49763 Q53XY6 Q86TW6	L7RSL3 P17948
PDB IDs		1FZV 1RV6	1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Vestibulocochlear Nerve Structural Organization Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Ganglion Morphogenesis Patterning Of Blood Vessels Angiogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Sprouting Angiogenesis Positive Regulation Of Cellular Component Movement Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Locomotion Sensory Neuron Axon Guidance Positive Regulation Of Endothelial Cell Proliferation Blood Vessel Morphogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Epithelial Cell Migration Pattern Specification Process Facioacoustic Ganglion Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Regulation Of Endothelial Cell Proliferation Blood Vessel Development Vasculature Development Coronary Artery Morphogenesis Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Ventral Trunk Neural Crest Cell Migration Regulation Of Endothelial Cell Migration Cellular Response To Growth Factor Stimulus Hypothalamus Cell Migration Neural Crest Cell Migration Involved In Autonomic Nervous System Development Trigeminal Ganglion Development Regulation Of Cell Migration Response To Growth Factor Chemotaxis Endothelial Cell Chemotaxis Positive Regulation Of Axon Extension Involved In Axon Guidance Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Regulation Of Cell Motility Tissue Morphogenesis Hypothalamus Cell Differentiation Vestibulocochlear Nerve Development Axon Extension Involved In Axon Guidance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Sympathetic Ganglion Development	Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Signal Transduction Response To Organic Substance Regulation Of Intracellular Signal Transduction Locomotion Signaling Cell Communication Cellular Response To Peptide Hormone Stimulus Anatomical Structure Morphogenesis Cellular Response To Peptide Cell Migration Innate Immune Response Response To Stress Cell Motility Cell Development Regulation Of Signal Transduction Cellular Response To Stimulus Fc Receptor Signaling Pathway Blood Vessel Morphogenesis Cellular Response To Hormone Stimulus Cell Differentiation Immune Response Regulation Of Immune System Process Blood Coagulation Hemostasis Defense Response Positive Regulation Of MAPK Cascade Anatomical Structure Development Regulation Of MAPK Cascade Angiogenesis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Neuron Differentiation Regulation Of Signaling Response To Peptide Immune System Process Cell Activation Blood Vessel Development Movement Of Cell Or Subcellular Component Regulation Of Cell Proliferation Cell Morphogenesis Involved In Differentiation Vasculature Development
Tagcloud ?		14c aa adrenergic arachidonate ciliary diacylglycerol esterification f2 glyceride ibc icb inasmuch indomethacin iris keto ocular pgd2 pge2 pgf2 pgs phenoxybenzamine phenylephrine prostaglandins stores superfused supplying tentatively thromboxane	abstract bace2 cleaving consecutively eclampsia endoglin eng fms fourth gynecology hif1a hypertensive hypoxia longitudinal mif milan multisystem obstetrics onwards pe pregnancies principally raffaele reaching sampled san seemed singleton worldwide
Tagcloud (Difference) ?		14c aa adrenergic arachidonate ciliary diacylglycerol esterification f2 glyceride ibc icb inasmuch indomethacin iris keto ocular pgd2 pge2 pgf2 pgs phenoxybenzamine phenylephrine prostaglandins stores superfused supplying tentatively thromboxane	abstract bace2 cleaving consecutively eclampsia endoglin eng fms fourth gynecology hif1a hypertensive hypoxia longitudinal mif milan multisystem obstetrics onwards pe pregnancies principally raffaele reaching sampled san seemed singleton worldwide
Tagcloud (Intersection) ?