PGF and NRP2

Number of citations of the paper that reports this interaction (PMID 10748121)
72

Data Source:
HPRD (in vivo)

		PGF	NRP2
Gene Name		placental growth factor	neuropilin 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Metal Ion Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Proliferation Cell Differentiation Organ Regeneration Cellular Response To Hormone Stimulus Response To Drug Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Division Regulation Of Morphogenesis Of A Branching Structure	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Nerve Development Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Involved In Axon Guidance Sympathetic Ganglion Development Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF	Axon guidance Signaling by VEGF Neurophilin interactions with VEGF and VEGFR L1CAM interactions NrCAM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: FLT1 NRP1 NRP2 VEGFA	8 interactors: FLT1 NRP1 PGF SEMA3B SEMA3C SEMA3F SEMA4F VEGFA
Entrez ID		5228	8828
HPRD ID		03076	03643
Ensembl ID		ENSG00000119630	ENSG00000118257
Uniprot IDs		G3XA84 P49763 Q53XY6 Q86TW6	O60462 Q7LBX6 Q7Z3T9
PDB IDs		1FZV 1RV6	2QQJ 2QQK 2QQL 2QQO
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Vestibulocochlear Nerve Structural Organization Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Ganglion Morphogenesis Patterning Of Blood Vessels Angiogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Sprouting Angiogenesis Positive Regulation Of Cellular Component Movement Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Locomotion Sensory Neuron Axon Guidance Positive Regulation Of Endothelial Cell Proliferation Blood Vessel Morphogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Epithelial Cell Migration Pattern Specification Process Facioacoustic Ganglion Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Regulation Of Endothelial Cell Proliferation Blood Vessel Development Vasculature Development Coronary Artery Morphogenesis Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Ventral Trunk Neural Crest Cell Migration Regulation Of Endothelial Cell Migration Cellular Response To Growth Factor Stimulus Hypothalamus Cell Migration Neural Crest Cell Migration Involved In Autonomic Nervous System Development Trigeminal Ganglion Development Regulation Of Cell Migration Response To Growth Factor Chemotaxis Endothelial Cell Chemotaxis Positive Regulation Of Axon Extension Involved In Axon Guidance Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Regulation Of Cell Motility Tissue Morphogenesis Hypothalamus Cell Differentiation Vestibulocochlear Nerve Development Axon Extension Involved In Axon Guidance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Sympathetic Ganglion Development	Chemotaxis Axon Guidance Sprouting Angiogenesis Axonogenesis Axon Development Regulation Of Axon Extension Morphogenesis Of A Branching Epithelium Cell Morphogenesis Involved In Neuron Differentiation Morphogenesis Of A Branching Structure Locomotion Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Negative Regulation Of Axon Extension Cell Part Morphogenesis Regulation Of Cell Size Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Neuron Development Response To External Stimulus Regulation Of Axonogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Pattern Specification Process Ameboidal-type Cell Migration Cell Differentiation Cell Morphogenesis Blood Vessel Development Morphogenesis Of An Epithelium Neuron Differentiation Vasculature Development Cell Projection Organization Branching Morphogenesis Of An Epithelial Tube Patterning Of Blood Vessels Neural Crest Cell Migration Regulation Of Retinal Ganglion Cell Axon Guidance Tissue Morphogenesis Positive Regulation Of Endothelial Cell Proliferation System Development Negative Regulation Of Axonogenesis Neural Crest Cell Development Tube Development Coronary Artery Morphogenesis Regulation Of Developmental Growth Trigeminal Nerve Structural Organization
Tagcloud ?		14c aa adrenergic arachidonate ciliary diacylglycerol esterification f2 glyceride ibc icb inasmuch indomethacin iris keto ocular pgd2 pge2 pgf2 pgs phenoxybenzamine phenylephrine prostaglandins stores superfused supplying tentatively thromboxane	10a 200c 30a 30c arhgap5 cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?		14c aa adrenergic arachidonate ciliary diacylglycerol esterification f2 glyceride ibc icb inasmuch indomethacin iris keto ocular pgd2 pge2 pgf2 pgs phenoxybenzamine phenylephrine prostaglandins stores superfused supplying tentatively thromboxane	10a 200c 30a 30c arhgap5 cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?