PGF and NRP1

Number of citations of the paper that reports this interaction (PMID 11986311)
45

Data Source:
HPRD (in vivo, in vitro)

		PGF	NRP1
Gene Name		placental growth factor	neuropilin 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Sorting Endosome
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Proliferation Cell Differentiation Organ Regeneration Cellular Response To Hormone Stimulus Response To Drug Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Division Regulation Of Morphogenesis Of A Branching Structure	Angiogenesis Patterning Of Blood Vessels Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Axon Guidance Axonal Fasciculation Response To Wounding Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Retinal Ganglion Cell Axon Guidance Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration VEGF-activated Neuropilin Signaling Pathway Otic Placode Formation Negative Regulation Of Neuron Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Ganglion Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Neural Crest Cell Migration Involved In Autonomic Nervous System Development Toxin Transport Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Protein Localization To Early Endosome Facioacoustic Ganglion Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF	Signal transduction by L1 CHL1 interactions Axon guidance Semaphorin interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Neurophilin interactions with VEGF and VEGFR L1CAM interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS			Schizophrenia ( 21682944) Tetralogy of Fallot ( 23297363)
Protein-Protein Interactions		4 interactors: FLT1 NRP1 NRP2 VEGFA	22 interactors: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB
Entrez ID		5228	8829
HPRD ID		03076	03642
Ensembl ID		ENSG00000119630	ENSG00000099250
Uniprot IDs		G3XA84 P49763 Q53XY6 Q86TW6	A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9
PDB IDs		1FZV 1RV6	1KEX 2QQI 2QQM 2QQN 3I97 4DEQ
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Vestibulocochlear Nerve Structural Organization Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Ganglion Morphogenesis Patterning Of Blood Vessels Angiogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Sprouting Angiogenesis Positive Regulation Of Cellular Component Movement Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Locomotion Sensory Neuron Axon Guidance Positive Regulation Of Endothelial Cell Proliferation Blood Vessel Morphogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Epithelial Cell Migration Pattern Specification Process Facioacoustic Ganglion Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Regulation Of Endothelial Cell Proliferation Blood Vessel Development Vasculature Development Coronary Artery Morphogenesis Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Ventral Trunk Neural Crest Cell Migration Regulation Of Endothelial Cell Migration Cellular Response To Growth Factor Stimulus Hypothalamus Cell Migration Neural Crest Cell Migration Involved In Autonomic Nervous System Development Trigeminal Ganglion Development Regulation Of Cell Migration Response To Growth Factor Chemotaxis Endothelial Cell Chemotaxis Positive Regulation Of Axon Extension Involved In Axon Guidance Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Regulation Of Cell Motility Tissue Morphogenesis Hypothalamus Cell Differentiation Vestibulocochlear Nerve Development Axon Extension Involved In Axon Guidance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Sympathetic Ganglion Development	Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Locomotion Regulation Of Epithelial Cell Migration Tissue Morphogenesis Regulation Of Locomotion Blood Vessel Development Vasculature Development Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Proliferation Tissue Development Regulation Of Cell Motility Angiogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Component Movement Morphogenesis Of An Epithelium Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Ameboidal-type Cell Migration Blood Vessel Morphogenesis Regulation Of Epithelial Cell Proliferation Cell Migration Embryo Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Cell Motility Positive Regulation Of Cell Division Positive Regulation Of Cell Migration System Development Positive Regulation Of Cell Motility Positive Regulation Of Angiogenesis Positive Regulation Of Locomotion Regulation Of Chemotaxis Organ Development Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Endothelial Cell Proliferation Cell Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Regulation Of Behavior
Tagcloud ?		14c aa adrenergic arachidonate ciliary diacylglycerol esterification f2 glyceride ibc icb inasmuch indomethacin iris keto ocular pgd2 pge2 pgf2 pgs phenoxybenzamine phenylephrine prostaglandins stores superfused supplying tentatively thromboxane	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Difference) ?		14c aa adrenergic arachidonate ciliary diacylglycerol esterification f2 glyceride ibc icb inasmuch indomethacin iris keto ocular pgd2 pge2 pgf2 pgs phenoxybenzamine phenylephrine prostaglandins stores superfused supplying tentatively thromboxane	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Intersection) ?