FGF4 and FGFR1

Number of citations of the paper that reports this interaction (PMID 11486033)
11

Data Source:
HPRD (in vitro)

		FGF4	FGFR1
Gene Name		fibroblast growth factor 4	fibroblast growth factor receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytosol	Extracellular Region Nucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Receptor Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cartilage Condensation Positive Regulation Of Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Mesenchymal Cell Proliferation Stem Cell Maintenance Embryonic Hindlimb Morphogenesis Fc-epsilon Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cell Division Cranial Suture Morphogenesis Apoptotic Process Involved In Morphogenesis Chondroblast Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Angiogenesis Ureteric Bud Development In Utero Embryonic Development Organ Induction Neuron Migration Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Transcription, DNA-templated Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Ventricular Zone Neuroblast Division Embryonic Limb Morphogenesis Midbrain Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fc-epsilon Receptor Signaling Pathway Inner Ear Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Chordate Embryonic Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Paraxial Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Cell Maturation Skeletal System Morphogenesis Mesenchymal Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Auditory Receptor Cell Development Branching Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Signaling by FGFR in disease Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants Signaling by FGFR mutants
Drugs		Pentosan Polysulfate
Diseases
GWAS		Breast cancer ( 20453838)
Protein-Protein Interactions		5 interactors: FGFR1 FGFR2 FGFR3 FGFR4 NRP1	45 interactors: BNIP2 CREBBP CRK CTPS2 EPHA4 ERBB3 FDPS FGF1 FGF17 FGF18 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FLRT3 FRS2 FRS3 GRB14 GRB2 IL17RD ITK KPNB1 MMP2 NCAM1 NCK1 NCK2 NEDD4 NRP1 PIK3R1 PIK3R2 PLCG1 PTK6 RPS6KA1 RPS6KA3 RTN3 SH3BP2 SHC1 SLA SOS1 TNS2 VAV1
Entrez ID		2249	2260
HPRD ID		01294	00634
Ensembl ID		ENSG00000075388	ENSG00000077782
Uniprot IDs		B7U994 P08620	P11362
PDB IDs		1IJT	1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 4F63 4F64 4F65
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Phosphorylation Cell Fate Commitment Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Branching Involved In Salivary Gland Morphogenesis Inner Ear Development Regulation Of ERK1 And ERK2 Cascade Tube Development Protein Autophosphorylation Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Ear Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Salivary Gland Morphogenesis Lung Development Respiratory Tube Development Positive Regulation Of Phosphorylation Salivary Gland Development Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Cell-cell Signaling Lung Alveolus Development Ventricular Zone Neuroblast Division Peptidyl-amino Acid Modification Respiratory System Development Regulation Of Developmental Growth Response To Insulin Exocrine System Development Stem Cell Differentiation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Orbitofrontal Cortex Development Epithelium Development Immune Response-regulating Cell Surface Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Fc Receptor Signaling Pathway Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Immune Response Immune Response Cellular Response To Insulin Stimulus Cellular Response To Organic Substance Defense Response Cell Surface Receptor Signaling Pathway Response To Insulin Regulation Of Immune System Process Cellular Response To Peptide Hormone Stimulus Immune System Process Cellular Response To Peptide Signal Transduction Cellular Response To Organonitrogen Compound Response To Organic Substance Signaling Cell Communication Response To Peptide Hormone Response To Peptide Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cellular Response To Stimulus Response To Stress Locomotion Positive Regulation Of Signal Transduction Response To Organonitrogen Compound System Development Chemotaxis Multicellular Organismal Development Cell Differentiation Response To Hormone Regulation Of Phosphorylation Anatomical Structure Development
Tagcloud ?		11q13 4nqo 7f4 amplicon amplification amplified cavity ccnd1 chr distal example fgf3 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold	abrogated abrogation acetic antiproliferative aromatic arteriosclerosis compete dimerization embedded f32 former heparan heparin heparinase hs hydroxyphenoxy kd microvessel mimics mitogenic nonsulfated nontoxic outgrowth polyanionic proteoglycans restenosis rg rings
Tagcloud (Difference) ?		11q13 4nqo 7f4 amplicon amplification amplified cavity ccnd1 chr distal example fgf3 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold	abrogated abrogation acetic antiproliferative aromatic arteriosclerosis compete dimerization embedded f32 former heparan heparin heparinase hs hydroxyphenoxy kd microvessel mimics mitogenic nonsulfated nontoxic outgrowth polyanionic proteoglycans restenosis rg rings
Tagcloud (Intersection) ?