FGF4 and FGFR4

Number of citations of the paper that reports this interaction (PMID 8663044)
243

Data Source:
HPRD (in vitro)

		FGF4	FGFR4
Gene Name		fibroblast growth factor 4	fibroblast growth factor receptor 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytosol	Extracellular Region Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Transport Vesicle
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding
	Biological Process	Cartilage Condensation Positive Regulation Of Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Mesenchymal Cell Proliferation Stem Cell Maintenance Embryonic Hindlimb Morphogenesis Fc-epsilon Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cell Division Cranial Suture Morphogenesis Apoptotic Process Involved In Morphogenesis Chondroblast Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Organ Induction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Lipid Metabolic Process Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Innate Immune Response Positive Regulation Of Proteolysis Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Metalloenzyme Activity Phosphate Ion Homeostasis Alveolar Secondary Septum Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Bile Acid Biosynthetic Process Response To Bile Acid Regulation Of Cholesterol Homeostasis Positive Regulation Of DNA Biosynthetic Process
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Signaling by FGFR4 mutants PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer betaKlotho-mediated ligand binding Signaling by FGFR Klotho-mediated ligand binding FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs		Pentosan Polysulfate	Palifermin Ponatinib
Diseases
GWAS		Breast cancer ( 20453838)	Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		5 interactors: FGFR1 FGFR2 FGFR3 FGFR4 NRP1	17 interactors: CDH2 EPHA4 FGF1 FGF17 FGF18 FGF19 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 PLCG1 STAT1 STAT3
Entrez ID		2249	2264
HPRD ID		01294	00625
Ensembl ID		ENSG00000075388	ENSG00000160867
Uniprot IDs		B7U994 P08620	G3JVM2 J3KPQ0 P22455 Q96KE5
PDB IDs		1IJT	1QCT
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Phosphorylation Cell Fate Commitment Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Branching Involved In Salivary Gland Morphogenesis Inner Ear Development Regulation Of ERK1 And ERK2 Cascade Tube Development Protein Autophosphorylation Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Ear Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Salivary Gland Morphogenesis Lung Development Respiratory Tube Development Positive Regulation Of Phosphorylation Salivary Gland Development Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Cell-cell Signaling Lung Alveolus Development Ventricular Zone Neuroblast Division Peptidyl-amino Acid Modification Respiratory System Development Regulation Of Developmental Growth Response To Insulin Exocrine System Development Stem Cell Differentiation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Orbitofrontal Cortex Development Epithelium Development Immune Response-regulating Cell Surface Receptor Signaling Pathway	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Peptide Phosphatidylinositol-mediated Signaling Fc-epsilon Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Insulin Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Response To Growth Factor Immune Response-regulating Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Regulation Of Immune Response Response To Hormone Defense Response Positive Regulation Of Cell Division Positive Regulation Of Cell Proliferation Immune Response Regulation Of Immune System Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Cell Proliferation Regulation Of Cell Division Cell Surface Receptor Signaling Pathway System Development Response To Organic Substance Immune System Process Multicellular Organismal Development Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Anatomical Structure Development Positive Regulation Of MAPK Cascade Developmental Process Cell Differentiation Response To Stress Positive Regulation Of Phosphorylation
Tagcloud ?		11q13 4nqo 7f4 amplicon amplification amplified cavity ccnd1 chr distal example fgf3 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold	5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Difference) ?		11q13 4nqo 7f4 amplicon amplification amplified cavity ccnd1 chr distal example fgf3 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic thirds twofold	5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated vicinity wiaf
Tagcloud (Intersection) ?		telomeric