FGF4 and FGFR2

Number of citations of the paper that reports this interaction (PubMedID 8663044)
0

Data Source:
HPRD (in vitro)

		FGF4	FGFR2
Description		fibroblast growth factor 4	fibroblast growth factor receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Cell Cortex Cell Surface Membrane Cytoplasmic Vesicle Receptor Complex Excitatory Synapse
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Activity Protein Binding ATP Binding Heparin Binding Kinase Activity Transferase Activity Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cartilage Condensation Apoptotic Process Signal Transduction Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Mesenchymal Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Gene Expression Stem Cell Population Maintenance Neurogenesis Cell Differentiation Embryonic Limb Morphogenesis Regulation Of Cell Migration Somatic Stem Cell Population Maintenance Embryonic Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division Cranial Suture Morphogenesis Apoptotic Process Involved In Morphogenesis Chondroblast Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Stem Cell Proliferation Epithelial Cell Apoptotic Process Cellular Response To Leukemia Inhibitory Factor Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Stem Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ureteric Bud Development In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Mesenchymal Cell Proliferation Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Endochondral Bone Growth Apoptotic Process Cell-cell Signaling Axonogenesis Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Post-embryonic Development Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Phospholipase Activity Negative Regulation Of Keratinocyte Proliferation Morphogenesis Of Embryonic Epithelium Peptidyl-tyrosine Phosphorylation Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Pyramidal Neuron Development Gland Morphogenesis Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Lung Development Epithelial Cell Differentiation Midbrain Development Otic Vesicle Formation Hair Follicle Morphogenesis Response To Lipopolysaccharide Lacrimal Gland Development Regulation Of Osteoblast Proliferation Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Inner Ear Morphogenesis Odontogenesis Chordate Embryonic Development Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Cell Fate Commitment Response To Ethanol Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Lung Alveolus Development Mesodermal Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Embryonic Organ Development Reproductive Structure Development Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Epidermis Morphogenesis Branching Morphogenesis Of A Nerve Mesenchymal Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cell Division Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Limb Bud Formation Bone Development Bone Morphogenesis Branching Involved In Prostate Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Elongation Involved In Lung Branching Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Gland Morphogenesis Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Lateral Sprouting From An Epithelium Mammary Gland Bud Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Branch Elongation Involved In Salivary Gland Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Mesenchymal Cell Differentiation Involved In Lung Development Mesenchymal Cell Proliferation Involved In Lung Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Cranial Skeletal System Development
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Specification of the neural plate border Developmental Lineage of Multipotent Pancreatic Progenitor Cells	Signaling by FGFR2 amplification mutants Activated point mutants of FGFR2 Signaling by FGFR2 in disease Signaling by FGFR2 IIIa TM Signaling by FGFR2 fusions
Drugs		Pentosan polysulfate Heparin TP-508	Palifermin Heparin Sucrosofate 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Infigratinib Fostamatinib Erdafitinib Pemigatinib Futibatinib Selpercatinib Pralsetinib
Diseases			Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome Gastric cancer Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Birth weight ( 31043758) Breast cancer ( 20453838) Craniofacial microsomia ( 26853712) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Urate levels in overweight individuals ( 25811787)	Adiponectin levels ( 24105470) Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Body mass index ( 28892062) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 17529973 31757997 29059683 25956309 24143190 23354978 22951594 21263130 19330030 20453838 20872241 23535729 17529967) Breast cancer (early onset) ( 24493630) Breast cancer (estrogen-receptor positive) ( 28864454) Breast cancer (progesterone-receptor positive) ( 28864454) Breast cancer in BRCA2 mutation carriers ( 23544012 21060860) Cancer (pleiotropy) ( 27197191) Childhood ear infection ( 27182965) Core binding factor acute myeloid leukemia ( 27903959) Coronary artery disease ( 32469254) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estrogen receptor status in breast cancer ( 27764800) Estrogen receptor status in HER2 negative breast cancer ( 27764800) High density lipoprotein cholesterol levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Magnesium levels ( 26685716) PR interval ( 32439900) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 30410027 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926 32499647) Vaginal microbiome composition (L. iners) ( 32723796) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 NRP1	45 interacting genes: ANOS1 APP BEX1 BEX2 CACNA1D CTDSP1 CTDSPL DUSP14 EPHA4 ERBB2 ERRFI1 FBXO7 FGF1 FGF10 FGF17 FGF18 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GLCE HOXC6 ITGA5 LRRK1 MTA3 MTMR3 NECTIN1 NEDD4 PAK4 PDLIM2 PLCG1 PPM1A PTK2B PTPN11 PTPN12 PTPRR RASL10B RHOBTB2 S100A14 SHC1 TFF1
Entrez ID		2249	2263
HPRD ID		01294	01492
Ensembl ID		ENSG00000075388	ENSG00000066468
Uniprot IDs		A0A7U3JW12 P08620	A0A141AXF1 D2CGD1 P21802 S4R381
PDB IDs		1IJT	1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU 3OJ2 3OJM 3RI1 4J23 4J95 4J96 4J97 4J98 4J99 4WV1 5EG3 5UGL 5UGX 5UHN 5UI0 6AGX 6LVK 6LVL 6V6Q 7KIA 7KIE 7OZY 8E1X 8H75 8STG 8SWE 8U1F 8W2X 8W38 8W3B 8W3D
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Lipase Activity Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Heparin Binding Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of ERK1 And ERK2 Cascade Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Catalytic Activity Regulation Of Developmental Growth Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Intracellular Signal Transduction Biomineral Tissue Development Lung-associated Mesenchyme Development Endochondral Bone Growth Positive Regulation Of Hydrolase Activity Protein Autophosphorylation Protein Kinase Activity Animal Organ Morphogenesis Branching Involved In Salivary Gland Morphogenesis Regulation Of Catalytic Activity Positive Regulation Of Signal Transduction Morphogenesis Of A Branching Epithelium Cell-cell Signaling Regulation Of Growth Regulation Of Cell Population Proliferation Morphogenesis Of A Branching Structure Kinase Activity Positive Regulation Of Developmental Growth Signaling Bone Growth Neuron Development Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tissue Development Positive Regulation Of Epithelial Cell Proliferation	Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Growth Factor Activity Neurogenesis Fibroblast Growth Factor Receptor Binding Regulation Of ERK1 And ERK2 Cascade Regulation Of Locomotion Type 2 Fibroblast Growth Factor Receptor Binding Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Motility Positive Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Division Type 1 Fibroblast Growth Factor Receptor Binding Signal Transduction ERBB Signaling Pathway Protein Dephosphorylation Phosphoprotein Phosphatase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Developmental Process Developmental Process Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Division Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Motility Dephosphorylation Cellular Response To Growth Factor Stimulus Positive Regulation Of Locomotion Regulation Of Anatomical Structure Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Multicellular Organismal Process Response To Growth Factor Protein Tyrosine Phosphatase Activity Heparin Binding Response To Epidermal Growth Factor Lung Development
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