FGF4

Name	fibroblast growth factor 4
Structure
Interactors	5 interactors: FGFR1 FGFR2 FGFR3 FGFR4 NRP1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding
	Biological Process	Cartilage Condensation Apoptotic Process Signal Transduction Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Mesenchymal Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Gene Expression Stem Cell Population Maintenance Neurogenesis Cell Differentiation Embryonic Limb Morphogenesis Regulation Of Cell Migration Somatic Stem Cell Population Maintenance Embryonic Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division Cranial Suture Morphogenesis Apoptotic Process Involved In Morphogenesis Chondroblast Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Stem Cell Proliferation Epithelial Cell Apoptotic Process Cellular Response To Leukemia Inhibitory Factor Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Stem Cell Proliferation
Pathways	PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Specification of the neural plate border Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs	Pentosan polysulfate Heparin TP-508
GWAS	Birth weight ( 31043758 ) Breast cancer ( 20453838 ) Craniofacial microsomia ( 26853712 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Urate levels in overweight individuals ( 25811787 )
Entrez ID	2249
HPRD ID	01294
Ensembl ID	ENSG00000075388
Uniprot IDs	A0A7U3JW12 P08620
PDB IDs	1IJT
GO Terms Enriched among Interactors ?	Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Lipase Activity Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Heparin Binding Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of ERK1 And ERK2 Cascade Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Catalytic Activity Regulation Of Developmental Growth Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Intracellular Signal Transduction Biomineral Tissue Development Lung-associated Mesenchyme Development Endochondral Bone Growth Positive Regulation Of Hydrolase Activity Protein Autophosphorylation Protein Kinase Activity Animal Organ Morphogenesis Branching Involved In Salivary Gland Morphogenesis Regulation Of Catalytic Activity Positive Regulation Of Signal Transduction Morphogenesis Of A Branching Epithelium Cell-cell Signaling Regulation Of Growth Regulation Of Cell Population Proliferation Morphogenesis Of A Branching Structure Kinase Activity Positive Regulation Of Developmental Growth Signaling Bone Growth Neuron Development Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tissue Development Positive Regulation Of Epithelial Cell Proliferation