TIAM1 and ABCC5

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		TIAM1	ABCC5
Description		TIAM Rac1 associated GEF 1	ATP binding cassette subfamily C member 5
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Cell-cell Contact Zone Synapse Anchoring Junction	Endosome Golgi Apparatus Golgi Lumen Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Kinase Binding	Nucleotide Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Purine Nucleotide Transmembrane Transporter Activity Heme Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Macromolecule Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity Carbohydrate Derivative Transmembrane Transporter Activity
	Biological Process	Cell-matrix Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein-containing Complex Assembly Regulation Of Dopaminergic Neuron Differentiation	Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Purine Nucleotide Transport Hyaluronan Biosynthetic Process Glutathione Transmembrane Transport Heme Transmembrane Transport Xenobiotic Transport Transmembrane Transport CAMP Transport CGMP Transport Monoatomic Anion Transmembrane Transport Folate Transmembrane Transport Export Across Plasma Membrane Transport Across Blood-brain Barrier Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Activated NTRK2 signals through CDK5	Hyaluronan metabolism ABC-family proteins mediated transport Azathioprine ADME Paracetamol ADME
Drugs			Curcumin Curcumin sulfate
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Renal sinus fat ( 22044751) Waist circumference ( 28552196)	Anterior chamber depth ( 24603532) Basophil percentage of white cells ( 32888494) Eosinophil count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)
Interacting Genes		86 interacting genes: ABCA1 ABCC5 ABTB3 ANK1 AP2M1 ARHGEF10 ARRB1 ATG5 ATP1A2 ATP5MF BTRC CAMK2G CASK CCDC15 CD44 CDC42 CHD9 CREBBP CREBZF CRYAB CSNK1A1 DAAM2 DLG1 DLG4 DNAAF9 DPM1 DZIP1 EFNB1 ENPP5 EPHA2 FNDC3B GLUD1 H3-3A H3-3B HRAS HSD17B4 KRIT1 MAPK8IP1 MAPK8IP2 MAST1 MBD1 MYC NASP NEUROD2 NME1 NRBP1 OSBPL1A PARD3 POLR1C PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAB6A RAC1 RHOA RPL27A RYR3 SENP6 SGTA SHARPIN SMARCE1 SNRNP70 SNTA1 SOX10 SRC SRSF5 SYCP1 TBC1D23 TMED4 TOP1 UBC USP9X YWHAG ZBTB44 ZKSCAN4 ZNF133 ZNF292 ZNF34 ZNF350 ZNF558 ZNF793	5 interacting genes: AK2 RBP5 SERPINA3 SMC2 TIAM1
Entrez ID		7074	10057
HPRD ID		02820	06898
Ensembl ID		ENSG00000156299	ENSG00000114770
Uniprot IDs		A0A1B0GW57 A0A2X0TW27 A0A8V8TN84 Q13009	O15440
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR	8KCI 8WI2 8WI3 8WI4 8WI5
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cell Projection Assembly Protein Kinase C Signaling Regulation Of Signaling Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Cell-cell Junction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Cellular Component Assembly Protein-containing Complex Organization Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Localization Regulation Of Centromere Complex Assembly Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Nucleotide Binding ATP Binding Regulation Of System Process Regulation Of Biological Quality Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Negative Regulation Of Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Organelle Organization Cell Periphery Positive Regulation Of Rho Protein Signal Transduction Organelle Organization Regulation Of Cell Adhesion Ruffle Membrane Protein Serine Kinase Activity Phosphate-containing Compound Metabolic Process Protein-containing Complex Assembly	Extracellular Exosome ADP Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Nucleoside Monophosphate Phosphorylation Sperm Mitochondrial Sheath Nucleobase-containing Compound Kinase Activity Phosphotransferase Activity, Phosphate Group As Acceptor AMP Kinase Activity Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Nucleoside Diphosphate Biosynthetic Process Ribonucleoside Diphosphate Biosynthetic Process Lipid Binding Regulation Of Dopaminergic Neuron Differentiation Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Retinol Binding Retinal Binding Retinoid Binding Mitotic Chromosome Condensation Kinetochore Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?