TIAM1 and ZNF133

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		TIAM1	ZNF133
Description		TIAM Rac1 associated GEF 1	zinc finger protein 133
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Cell-cell Contact Zone Synapse Anchoring Junction	Nucleus
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Kinase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein-containing Complex Assembly Regulation Of Dopaminergic Neuron Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Activated NTRK2 signals through CDK5	Generic Transcription Pathway
Drugs
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Renal sinus fat ( 22044751) Waist circumference ( 28552196)	Body mass index ( 28892062 29273807) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		86 interacting genes: ABCA1 ABCC5 ABTB3 ANK1 AP2M1 ARHGEF10 ARRB1 ATG5 ATP1A2 ATP5MF BTRC CAMK2G CASK CCDC15 CD44 CDC42 CHD9 CREBBP CREBZF CRYAB CSNK1A1 DAAM2 DLG1 DLG4 DNAAF9 DPM1 DZIP1 EFNB1 ENPP5 EPHA2 FNDC3B GLUD1 H3-3A H3-3B HRAS HSD17B4 KRIT1 MAPK8IP1 MAPK8IP2 MAST1 MBD1 MYC NASP NEUROD2 NME1 NRBP1 OSBPL1A PARD3 POLR1C PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAB6A RAC1 RHOA RPL27A RYR3 SENP6 SGTA SHARPIN SMARCE1 SNRNP70 SNTA1 SOX10 SRC SRSF5 SYCP1 TBC1D23 TMED4 TOP1 UBC USP9X YWHAG ZBTB44 ZKSCAN4 ZNF133 ZNF292 ZNF34 ZNF350 ZNF558 ZNF793	9 interacting genes: APP FOS ILK KRTAP10-7 MAPK6 MDM2 PDPK1 TIAM1 TRIM28
Entrez ID		7074	7692
HPRD ID		02820	04964
Ensembl ID		ENSG00000156299	ENSG00000125846
Uniprot IDs		A0A1B0GW57 A0A2X0TW27 A0A8V8TN84 Q13009	P52736
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cell Projection Assembly Protein Kinase C Signaling Regulation Of Signaling Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Cell-cell Junction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Cellular Component Assembly Protein-containing Complex Organization Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Localization Regulation Of Centromere Complex Assembly Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Nucleotide Binding ATP Binding Regulation Of System Process Regulation Of Biological Quality Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Negative Regulation Of Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Organelle Organization Cell Periphery Positive Regulation Of Rho Protein Signal Transduction Organelle Organization Regulation Of Cell Adhesion Ruffle Membrane Protein Serine Kinase Activity Phosphate-containing Compound Metabolic Process Protein-containing Complex Assembly	Positive Regulation Of Developmental Process Intracellular Signaling Cassette Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Positive Regulation Of Protein Localization SUMO Transferase Activity Response To Immobilization Stress Cellular Response To Peptide Hormone Stimulus Protein Kinase Activity Amyloid Fibril Formation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Transport Cellular Response To Epidermal Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Response To Metal Ion Response To Light Stimulus Positive Regulation Of Establishment Of Protein Localization Regulation Of Cell Differentiation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein-containing Complex Positive Regulation Of Transport Glial Cell Development Response To Peptide Hormone Response To Epidermal Growth Factor Medium-term Memory Cellular Response To Prolactin Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of Nucleocytoplasmic Transport Protein Sumoylation 3-phosphoinositide-dependent Protein Kinase Activity Cytosol Cellular Response To Hormone Stimulus Promoter-specific Chromatin Binding Cellular Response To Oxygen-containing Compound Regulation Of MiRNA Transcription Regulation Of Receptor Internalization Regulation Of Cell Population Proliferation Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Acetylcholine Receptor Activator Activity
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