TIAM1 and RPL27A

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		TIAM1	RPL27A
Description		TIAM Rac1 associated GEF 1	ribosomal protein L27a
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Cell-cell Contact Zone Synapse Anchoring Junction	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Ribonucleoprotein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Kinase Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein-containing Complex Assembly Regulation Of Dopaminergic Neuron Differentiation	Cytoplasmic Translation Translation
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Activated NTRK2 signals through CDK5	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Protein hydroxylation Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Renal sinus fat ( 22044751) Waist circumference ( 28552196)	Body mass index ( 20935630 26426971 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Fruit consumption ( 32066663) Obesity ( 23563607)
Interacting Genes		86 interacting genes: ABCA1 ABCC5 ABTB3 ANK1 AP2M1 ARHGEF10 ARRB1 ATG5 ATP1A2 ATP5MF BTRC CAMK2G CASK CCDC15 CD44 CDC42 CHD9 CREBBP CREBZF CRYAB CSNK1A1 DAAM2 DLG1 DLG4 DNAAF9 DPM1 DZIP1 EFNB1 ENPP5 EPHA2 FNDC3B GLUD1 H3-3A H3-3B HRAS HSD17B4 KRIT1 MAPK8IP1 MAPK8IP2 MAST1 MBD1 MYC NASP NEUROD2 NME1 NRBP1 OSBPL1A PARD3 POLR1C PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAB6A RAC1 RHOA RPL27A RYR3 SENP6 SGTA SHARPIN SMARCE1 SNRNP70 SNTA1 SOX10 SRC SRSF5 SYCP1 TBC1D23 TMED4 TOP1 UBC USP9X YWHAG ZBTB44 ZKSCAN4 ZNF133 ZNF292 ZNF34 ZNF350 ZNF558 ZNF793	7 interacting genes: DUX4 GTF2F2 PEX6 PRKACB PTEN SIAH1 TIAM1
Entrez ID		7074	6157
HPRD ID		02820	04701
Ensembl ID		ENSG00000156299	ENSG00000166441
Uniprot IDs		A0A1B0GW57 A0A2X0TW27 A0A8V8TN84 Q13009	P46776
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR	4BXF 4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cell Projection Assembly Protein Kinase C Signaling Regulation Of Signaling Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Cell-cell Junction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Cellular Component Assembly Protein-containing Complex Organization Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Localization Regulation Of Centromere Complex Assembly Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Nucleotide Binding ATP Binding Regulation Of System Process Regulation Of Biological Quality Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Negative Regulation Of Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Organelle Organization Cell Periphery Positive Regulation Of Rho Protein Signal Transduction Organelle Organization Regulation Of Cell Adhesion Ruffle Membrane Protein Serine Kinase Activity Phosphate-containing Compound Metabolic Process Protein-containing Complex Assembly
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