TIAM1 and ATP1A2

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		TIAM1	ATP1A2
Name		TIAM Rac1 associated GEF 1	ATPase Na+/K+ transporting subunit alpha 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Cell-cell Contact Zone Synapse Anchoring Junction	Cytoplasm Endosome Endoplasmic Reticulum Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Cell Surface Intercalated Disc Membrane T-tubule Organelle Membrane Protein-containing Complex Sarcolemma Cell Projection Neuronal Cell Body Dendritic Spine Extracellular Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Kinase Binding	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity Steroid Binding Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity Phosphatase Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Potassium Ion Binding Sodium Ion Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding Steroid Hormone Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein-containing Complex Assembly Regulation Of Dopaminergic Neuron Differentiation	Neurotransmitter Uptake Behavioral Fear Response Regulation Of The Force Of Heart Contraction Regulation Of Respiratory Gaseous Exchange By Nervous System Process Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Regulation Of Striated Muscle Contraction Cell Communication Blood Circulation Regulation Of Heart Contraction Regulation Of Blood Pressure Adult Locomotory Behavior Visual Learning Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Auditory Stimulus Neuronal Action Potential Propagation Regulation Of Vasoconstriction L-ascorbic Acid Metabolic Process Amygdala Development Olfactory Cortex Development Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Response To Nicotine Locomotory Exploration Behavior Sodium Ion Transmembrane Transport Response To Potassium Ion Sodium Ion Export Across Plasma Membrane Locomotion Fear Response Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Negative Regulation Of Striated Muscle Contraction ATP Metabolic Process Negative Regulation Of Cytosolic Calcium Ion Concentration Membrane Depolarization Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Regulation Of Synaptic Transmission, Glutamatergic Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Potassium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Monoatomic Cation Transmembrane Transport Transport Across Blood-brain Barrier Proton Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Response To Glycoside Potassium Ion Import Across Plasma Membrane
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Activated NTRK2 signals through CDK5	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		None	Ouabain Bisacodyl Tegoprazan
Diseases		None	Familial or sporadic hemiplegic migraine Alternating hemiplegia of childhood
GWAS		Cervical high-risk human papilloma virus infection ( 33225922 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Renal sinus fat ( 22044751 ) Waist circumference ( 28552196 )	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Response to antipsychotic treatment ( 23241943 )
Interacting Genes		86 interacting genes: ABCA1 ABCC5 ABTB3 ANK1 AP2M1 ARHGEF10 ARRB1 ATG5 ATP1A2 ATP5MF BTRC CAMK2G CASK CCDC15 CD44 CDC42 CHD9 CREBBP CREBZF CRYAB CSNK1A1 DAAM2 DLG1 DLG4 DNAAF9 DPM1 DZIP1 EFNB1 ENPP5 EPHA2 FNDC3B GLUD1 H3-3A H3-3B HRAS HSD17B4 KRIT1 MAPK8IP1 MAPK8IP2 MAST1 MBD1 MYC NASP NEUROD2 NME1 NRBP1 OSBPL1A PARD3 POLR1C PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAB6A RAC1 RHOA RPL27A RYR3 SENP6 SGTA SHARPIN SMARCE1 SNRNP70 SNTA1 SOX10 SRC SRSF5 SYCP1 TBC1D23 TMED4 TOP1 UBC USP9X YWHAG ZBTB44 ZKSCAN4 ZNF133 ZNF292 ZNF34 ZNF350 ZNF558 ZNF793	2 interacting genes: TIAM1 TPT1
Entrez ID		7074	477
HPRD ID		02820	01665
Ensembl ID		ENSG00000156299	ENSG00000018625
Uniprot IDs		A0A1B0GW57 A0A2X0TW27 A0A8V8TN84 Q13009	A0A0S2Z3W6 B4DIQ8 P50993
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR	Not available
GO Terms Enriched among Interactors		Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cell Projection Assembly Protein Kinase C Signaling Regulation Of Signaling Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Cell-cell Junction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Cellular Component Assembly Protein-containing Complex Organization Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Localization Regulation Of Centromere Complex Assembly Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Nucleotide Binding ATP Binding Regulation Of System Process Regulation Of Biological Quality Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Negative Regulation Of Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Organelle Organization Cell Periphery Positive Regulation Of Rho Protein Signal Transduction Organelle Organization Regulation Of Cell Adhesion Ruffle Membrane Protein Serine Kinase Activity Phosphate-containing Compound Metabolic Process Protein-containing Complex Assembly	Negative Regulation Of Ectoderm Development