TIAM1 and KRIT1

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		TIAM1	KRIT1
Name		TIAM Rac1 associated GEF 1	KRIT1 ankyrin repeat containing
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Cell-cell Contact Zone Synapse Anchoring Junction	Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Protein-containing Complex Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Kinase Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding GTPase Regulator Activity
	Biological Process	Cell-matrix Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein-containing Complex Assembly Regulation Of Dopaminergic Neuron Differentiation	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Endothelium Development Small GTPase-mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Integrin Activation Cell Redox Homeostasis Regulation Of Angiogenesis Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Activated NTRK2 signals through CDK5	None
Diseases		None	Cerebral cavernous malformation
GWAS		Cervical high-risk human papilloma virus infection ( 33225922 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Renal sinus fat ( 22044751 ) Waist circumference ( 28552196 )	Coffee consumption ( 31046077 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 )
Novel Interactors		1 novel interactors: GART	1 novel interactors: CDK6
Interacting Genes		86 interacting genes: ABCA1 ABCC5 ABTB3 ANK1 AP2M1 ARHGEF10 ARRB1 ATG5 ATP1A2 ATP5MF BTRC CAMK2G CASK CCDC15 CD44 CDC42 CHD9 CREBBP CREBZF CRYAB CSNK1A1 DAAM2 DLG1 DLG4 DNAAF9 DPM1 DZIP1 EFNB1 ENPP5 EPHA2 FNDC3B GLUD1 H3-3A H3-3B HRAS HSD17B4 KRIT1 MAPK8IP1 MAPK8IP2 MAST1 MBD1 MYC NASP NEUROD2 NME1 NRBP1 OSBPL1A PARD3 POLR1C PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAB6A RAC1 RHOA RPL27A RYR3 SENP6 SGTA SHARPIN SMARCE1 SNRNP70 SNTA1 SOX10 SRC SRSF5 SYCP1 TBC1D23 TMED4 TOP1 UBC USP9X YWHAG ZBTB44 ZKSCAN4 ZNF133 ZNF292 ZNF34 ZNF350 ZNF558 ZNF793	7 interacting genes: ITGB1BP1 PLCB3 RAP1A RGS4 TIAM1 TRPV4 UBE2K
Entrez ID		7074	889
HPRD ID		02820	05020
Ensembl ID		ENSG00000156299	ENSG00000001631
Uniprot IDs		A0A1B0GW57 A0A2X0TW27 A0A8V8TN84 Q13009	A4D1F7 O00522
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR	3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF 4TKN 5D68 6OQ3 6OQ4 6UZK 8SU8 8T09 8T7V
GO Terms Enriched among Interactors		Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cell Projection Assembly Protein Kinase C Signaling Regulation Of Signaling Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Cell-cell Junction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Cellular Component Assembly Protein-containing Complex Organization Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Localization Regulation Of Centromere Complex Assembly Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Nucleotide Binding ATP Binding Regulation Of System Process Regulation Of Biological Quality Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Negative Regulation Of Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Organelle Organization Cell Periphery Positive Regulation Of Rho Protein Signal Transduction Organelle Organization Regulation Of Cell Adhesion Ruffle Membrane Protein Serine Kinase Activity Phosphate-containing Compound Metabolic Process Protein-containing Complex Assembly	Signal Transduction Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex Regulation Of Cell Differentiation FBXO Family Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Signaling Protein Polymerization Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Calmodulin Binding Calcium Ion Transmembrane Import Into Cytosol Regulation Of Neuron Projection Development Regulation Of ERK1 And ERK2 Cascade Response To Antineoplastic Agent Anchoring Junction Negative Regulation Of Glycine Import Across Plasma Membrane Protein Kinase Binding Regulation Of Supramolecular Fiber Organization Osmosensor Activity Blood Vessel Endothelial Cell Delamination Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Stretch-activated, Monoatomic Cation-selective, Calcium Channel Activity Kinase Binding Ruffle Positive Regulation Of Cellular Component Organization Cell-matrix Adhesion Notch Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Dopamine Receptor Signaling Pathway Cellular Hypotonic Salinity Response Vasopressin Secretion Regulation Of Cell-matrix Adhesion Epithelial Cell Development Positive Regulation Of Cell-substrate Adhesion Protein-containing Complex Assembly Positive Regulation Of Protein Kinase Activity