TNFRSF10A and COL2A1

Number of citations of the paper that reports this interaction (PMID 9811967)
6

Data Source:
HPRD (in vivo)

		TNFRSF10A	COL2A1
Gene Name		tumor necrosis factor receptor superfamily, member 10a	collagen, type II, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protease Binding Receptor Activity Death Receptor Activity Protein Binding Transcription Factor Binding TRAIL Binding	Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Axon Guidance Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Inner Ear Morphogenesis Cartilage Development Palate Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Regulation by c-FLIP Death Receptor Signalling TRAIL signaling Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death Extrinsic Pathway	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625)
Protein-Protein Interactions		15 interactors: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD	33 interactors: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		8797	1280
HPRD ID		04679	00361
Ensembl ID			ENSG00000139219
Uniprot IDs		O00220	P02458
PDB IDs			1U5M 2FSE 2SEB
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Zymogen Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Protein Processing Cellular Response To Stimulus Toll-like Receptor Signaling Pathway Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Signaling Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macrophage Differentiation Regulation Of Signal Transduction Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity Regulation Of Proteolysis	Extracellular Matrix Organization Extracellular Structure Organization Connective Tissue Development Cartilage Development Skeletal System Development Anatomical Structure Morphogenesis Organ Morphogenesis System Development Multicellular Organismal Development Tissue Development Platelet Degranulation Anatomical Structure Development Positive Regulation Of Cell Migration Bone Development Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Growth Plate Cartilage Development Response To Wounding Extracellular Matrix Disassembly Organ Development Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Growth Factor Stimulus Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Hemostasis Response To Growth Factor Locomotion Collagen Catabolic Process Endochondral Bone Growth Regulation Of Epithelial Cell Migration Collagen Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Involved In Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Response To External Stimulus Regulation Of Cell Migration Organ Growth Platelet Activation Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Positive Regulation Of Endothelial Cell Migration Regulation Of Locomotion Bone Morphogenesis
Tagcloud ?		aa activator atm atmmutated b bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Difference) ?		aa activator atm atmmutated b bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Intersection) ?