TNFRSF10A and TRADD

Number of citations of the paper that reports this interaction (PMID 9430227)
92

Data Source:
HPRD (in vivo)

		TNFRSF10A	TRADD
Gene Name		tumor necrosis factor receptor superfamily, member 10a	TNFRSF1A-associated via death domain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleus Cytoplasm Cytosol Cytoskeleton Death-inducing Signaling Complex Receptor Complex Membrane Raft
	Molecular Function	Protease Binding Receptor Activity Death Receptor Activity Protein Binding Transcription Factor Binding TRAIL Binding	Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Kinase Binding Protein Complex Binding Identical Protein Binding Binding, Bridging Death Domain Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Positive Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Regulation by c-FLIP Death Receptor Signalling TRAIL signaling Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death Extrinsic Pathway	Regulation by c-FLIP Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625)
Protein-Protein Interactions		15 interactors: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD	24 interactors: BCL10 BIRC2 CNTRL DAPK1 FADD FAS GFRA1 HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP
Entrez ID		8797	8717
HPRD ID		04679	04610
Ensembl ID
Uniprot IDs		O00220	B3KQZ9 Q15628
PDB IDs			1F2H 1F3V
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Zymogen Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Protein Processing Cellular Response To Stimulus Toll-like Receptor Signaling Pathway Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Signaling Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macrophage Differentiation Regulation Of Signal Transduction Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity Regulation Of Proteolysis	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Signaling Pathway Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Tumor Necrosis Factor Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Peptidase Activity Cell Surface Receptor Signaling Pathway Regulation Of Endopeptidase Activity Cellular Response To Cytokine Stimulus Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Response To Cytokine Programmed Necrotic Cell Death Necrotic Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Organic Substance Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Necroptotic Signaling Pathway Zymogen Activation Negative Regulation Of Apoptotic Process Cellular Response To Organic Substance Signal Transduction Negative Regulation Of Programmed Cell Death Response To Mechanical Stimulus Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Necroptotic Process Signaling Cellular Response To Mechanical Stimulus Cell Communication Response To Abiotic Stimulus
Tagcloud ?		aa activator atm atmmutated b bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr traf traf1 transmit
Tagcloud (Difference) ?		aa activator atm atmmutated b bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr traf traf1 transmit
Tagcloud (Intersection) ?